Thiocamptothecin

Cristian Samorì, Andrea Guerrini, Greta Varchi, Franco Zunino, Giovanni Luca Beretta, Cristina Femoni, Ezio Bombardelli, Gabriele Fontana, Arturo Battaglia

Research output: Contribution to journalArticle

Abstract

The synthesis and the X-ray structure of 16a-thiocamptothecin (TCPT), the thiopyridone analog of camptothecin (CPT), are accomplished. The crystal contains two structurally identical, yet independent molecules. Both of them are connected to other molecules via two intermolecular hydrogen bonds. S-Methylation of TCPT leads to the cleavage of the C-ring. The cytotoxic activity of TCPT was evaluated against different human tumor cell lines using CPT as reference compound.

Original languageEnglish
Pages (from-to)3040-3044
Number of pages5
JournalJournal of Medicinal Chemistry
Volume51
Issue number10
DOIs
Publication statusPublished - May 22 2008

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Camptothecin
Molecules
Methylation
Tumor Cell Line
Tumors
Hydrogen
Hydrogen bonds
Cells
X-Rays
X rays
Crystals
16a-thiocamptothecin

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Samorì, C., Guerrini, A., Varchi, G., Zunino, F., Beretta, G. L., Femoni, C., ... Battaglia, A. (2008). Thiocamptothecin. Journal of Medicinal Chemistry, 51(10), 3040-3044. https://doi.org/10.1021/jm8001982

Thiocamptothecin. / Samorì, Cristian; Guerrini, Andrea; Varchi, Greta; Zunino, Franco; Beretta, Giovanni Luca; Femoni, Cristina; Bombardelli, Ezio; Fontana, Gabriele; Battaglia, Arturo.

In: Journal of Medicinal Chemistry, Vol. 51, No. 10, 22.05.2008, p. 3040-3044.

Research output: Contribution to journalArticle

Samorì, C, Guerrini, A, Varchi, G, Zunino, F, Beretta, GL, Femoni, C, Bombardelli, E, Fontana, G & Battaglia, A 2008, 'Thiocamptothecin', Journal of Medicinal Chemistry, vol. 51, no. 10, pp. 3040-3044. https://doi.org/10.1021/jm8001982
Samorì C, Guerrini A, Varchi G, Zunino F, Beretta GL, Femoni C et al. Thiocamptothecin. Journal of Medicinal Chemistry. 2008 May 22;51(10):3040-3044. https://doi.org/10.1021/jm8001982
Samorì, Cristian ; Guerrini, Andrea ; Varchi, Greta ; Zunino, Franco ; Beretta, Giovanni Luca ; Femoni, Cristina ; Bombardelli, Ezio ; Fontana, Gabriele ; Battaglia, Arturo. / Thiocamptothecin. In: Journal of Medicinal Chemistry. 2008 ; Vol. 51, No. 10. pp. 3040-3044.
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