Thiol modification and cell signalling in chemical toxicity

P. Nicotera, J. M. Dypbukt, A. D. Rossi, L. Manzo, S. Orrenius

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Exposure of cells to thiol oxidizing agents can result in the modification of key proteins involved in cell signalling. Such changes have been shown to affect agonist-stimulated phosphoinositide metabolism, activation of protein kinases and intracellular Ca2+ signals, which result in abnormalities in cell metabolisms and growth. Here, we show that moderate levels of oxidants potentiate growth signals and either enhance cell proliferation or facilitate cell differentiation, whereas inhibition of growth signals by higher oxidant concentrations can block cell proliferation and activate programmed cell death (PCD). Finally, a general alteration of multiple signalling pathways associated with increased catabolic reactions results in cell death by necrosis. Our data suggest that oxidant interaction with cell signalling systems may exert opposite effects, depending on the dose, and that oxidative reactions may either mimic growth factor stimulation and stimulate cell proliferation or inhibit growth signals and activate PCD, in the same cell systems.

Original languageEnglish
Pages (from-to)563-567
Number of pages5
JournalToxicology Letters
Volume64-65
Issue numberC
DOIs
Publication statusPublished - 1992

Fingerprint

Cell signaling
Sulfhydryl Compounds
Oxidants
Toxicity
Cell proliferation
Cell death
Cell Death
Cell Proliferation
Growth
Metabolism
Phosphatidylinositols
Cell Communication
Protein Kinases
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Necrosis
Chemical activation
Proteins

Keywords

  • Apoptosis
  • Ca
  • Growth factor
  • Metals
  • Oxidative stress

ASJC Scopus subject areas

  • Toxicology

Cite this

Nicotera, P., Dypbukt, J. M., Rossi, A. D., Manzo, L., & Orrenius, S. (1992). Thiol modification and cell signalling in chemical toxicity. Toxicology Letters, 64-65(C), 563-567. https://doi.org/10.1016/0378-4274(92)90232-9

Thiol modification and cell signalling in chemical toxicity. / Nicotera, P.; Dypbukt, J. M.; Rossi, A. D.; Manzo, L.; Orrenius, S.

In: Toxicology Letters, Vol. 64-65, No. C, 1992, p. 563-567.

Research output: Contribution to journalArticle

Nicotera, P, Dypbukt, JM, Rossi, AD, Manzo, L & Orrenius, S 1992, 'Thiol modification and cell signalling in chemical toxicity', Toxicology Letters, vol. 64-65, no. C, pp. 563-567. https://doi.org/10.1016/0378-4274(92)90232-9
Nicotera P, Dypbukt JM, Rossi AD, Manzo L, Orrenius S. Thiol modification and cell signalling in chemical toxicity. Toxicology Letters. 1992;64-65(C):563-567. https://doi.org/10.1016/0378-4274(92)90232-9
Nicotera, P. ; Dypbukt, J. M. ; Rossi, A. D. ; Manzo, L. ; Orrenius, S. / Thiol modification and cell signalling in chemical toxicity. In: Toxicology Letters. 1992 ; Vol. 64-65, No. C. pp. 563-567.
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