Abstract
Both environmental pollutants and cigarette smoke are risk factors for the occurrence of respiratory, cardiovascular and neoplastic diseases. A common pathophysiological mechanism for both environmental pollutants and cigarette smoke is the increased generation, due to both smoke and pollutants, of reactive oxygen species (ROS), with subsequent generation of oxidative stress. In 10 smokers (>20 cigarettes/day, mean age 53 y) the thiol redox status has been evaluated, i.e. the equilibrium between oxidized and reduced species, in blood and plasma, for cystein, cisteinylglycine, homocysteine and glutathion (GSH), both in basal conditions (T1) and 60 days (T2) after administration of a well known antioxidant, N-acetilcysteine (NAC). Results of the present study show no change in cystein levels, despite active administration of NAC, whereas a significant (p
| Original language | Italian |
|---|---|
| Pages (from-to) | 375-381 |
| Number of pages | 7 |
| Journal | GIMT - Giornale Italiano delle Malattie del Torace |
| Volume | 62 |
| Issue number | 6 |
| Publication status | Published - 2008 |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Markers per la valutazione dello stato redox dei tioli e dell'attività di antiossidanti in un modello di inquinamento voluttuario delle vie aeree (fumo di sigaretta). / Schiraldi, G. F.; Accinni, R.; Cetta, F.; Della Noce, C.; Caboni, G.; La Spina, T.; Allegra, L.
In: GIMT - Giornale Italiano delle Malattie del Torace, Vol. 62, No. 6, 2008, p. 375-381.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Markers per la valutazione dello stato redox dei tioli e dell'attività di antiossidanti in un modello di inquinamento voluttuario delle vie aeree (fumo di sigaretta)
AU - Schiraldi, G. F.
AU - Accinni, R.
AU - Cetta, F.
AU - Della Noce, C.
AU - Caboni, G.
AU - La Spina, T.
AU - Allegra, L.
PY - 2008
Y1 - 2008
N2 - Both environmental pollutants and cigarette smoke are risk factors for the occurrence of respiratory, cardiovascular and neoplastic diseases. A common pathophysiological mechanism for both environmental pollutants and cigarette smoke is the increased generation, due to both smoke and pollutants, of reactive oxygen species (ROS), with subsequent generation of oxidative stress. In 10 smokers (>20 cigarettes/day, mean age 53 y) the thiol redox status has been evaluated, i.e. the equilibrium between oxidized and reduced species, in blood and plasma, for cystein, cisteinylglycine, homocysteine and glutathion (GSH), both in basal conditions (T1) and 60 days (T2) after administration of a well known antioxidant, N-acetilcysteine (NAC). Results of the present study show no change in cystein levels, despite active administration of NAC, whereas a significant (p
AB - Both environmental pollutants and cigarette smoke are risk factors for the occurrence of respiratory, cardiovascular and neoplastic diseases. A common pathophysiological mechanism for both environmental pollutants and cigarette smoke is the increased generation, due to both smoke and pollutants, of reactive oxygen species (ROS), with subsequent generation of oxidative stress. In 10 smokers (>20 cigarettes/day, mean age 53 y) the thiol redox status has been evaluated, i.e. the equilibrium between oxidized and reduced species, in blood and plasma, for cystein, cisteinylglycine, homocysteine and glutathion (GSH), both in basal conditions (T1) and 60 days (T2) after administration of a well known antioxidant, N-acetilcysteine (NAC). Results of the present study show no change in cystein levels, despite active administration of NAC, whereas a significant (p
KW - Cigarette smoke
KW - Oxidative stress
KW - Redox balance
KW - Thiol concentration
UR - http://www.scopus.com/inward/record.url?scp=70349293810&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349293810&partnerID=8YFLogxK
M3 - Articolo
VL - 62
SP - 375
EP - 381
JO - GIMT - Giornale Italiano delle Malattie del Torace
JF - GIMT - Giornale Italiano delle Malattie del Torace
SN - 1127-0810
IS - 6
ER -