Markers per la valutazione dello stato redox dei tioli e dell'attività di antiossidanti in un modello di inquinamento voluttuario delle vie aeree (fumo di sigaretta)

Translated title of the contribution: Thiol redox status in a model of voluptuary airway pollution (cigarette smoke) and antioxidant activity

G. F. Schiraldi, R. Accinni, F. Cetta, C. Della Noce, G. Caboni, T. La Spina, L. Allegra

Research output: Contribution to journalArticlepeer-review

Abstract

Both environmental pollutants and cigarette smoke are risk factors for the occurrence of respiratory, cardiovascular and neoplastic diseases. A common pathophysiological mechanism for both environmental pollutants and cigarette smoke is the increased generation, due to both smoke and pollutants, of reactive oxygen species (ROS), with subsequent generation of oxidative stress. In 10 smokers (>20 cigarettes/day, mean age 53 y) the thiol redox status has been evaluated, i.e. the equilibrium between oxidized and reduced species, in blood and plasma, for cystein, cisteinylglycine, homocysteine and glutathion (GSH), both in basal conditions (T1) and 60 days (T2) after administration of a well known antioxidant, N-acetilcysteine (NAC). Results of the present study show no change in cystein levels, despite active administration of NAC, whereas a significant (p

Translated title of the contributionThiol redox status in a model of voluptuary airway pollution (cigarette smoke) and antioxidant activity
Original languageItalian
Pages (from-to)375-381
Number of pages7
JournalGIMT - Giornale Italiano delle Malattie del Torace
Volume62
Issue number6
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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