Markers per la valutazione dello stato redox dei tioli e dell'attività di antiossidanti in un modello di inquinamento voluttuario delle vie aeree (fumo di sigaretta)

Translated title of the contribution: Thiol redox status in a model of voluptuary airway pollution (cigarette smoke) and antioxidant activity

G. F. Schiraldi, R. Accinni, F. Cetta, C. Della Noce, G. Caboni, T. La Spina, L. Allegra

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Both environmental pollutants and cigarette smoke are risk factors for the occurrence of respiratory, cardiovascular and neoplastic diseases. A common pathophysiological mechanism for both environmental pollutants and cigarette smoke is the increased generation, due to both smoke and pollutants, of reactive oxygen species (ROS), with subsequent generation of oxidative stress. In 10 smokers (>20 cigarettes/day, mean age 53 y) the thiol redox status has been evaluated, i.e. the equilibrium between oxidized and reduced species, in blood and plasma, for cystein, cisteinylglycine, homocysteine and glutathion (GSH), both in basal conditions (T1) and 60 days (T2) after administration of a well known antioxidant, N-acetilcysteine (NAC). Results of the present study show no change in cystein levels, despite active administration of NAC, whereas a significant (p

Original languageItalian
Pages (from-to)375-381
Number of pages7
JournalGIMT - Giornale Italiano delle Malattie del Torace
Volume62
Issue number6
Publication statusPublished - 2008

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Sulfhydryl Compounds
Smoke
Tobacco Products
Oxidation-Reduction
Environmental Pollutants
Antioxidants
Homocysteine
Glutathione
Reactive Oxygen Species
Oxidative Stress
Cardiovascular Diseases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Markers per la valutazione dello stato redox dei tioli e dell'attività di antiossidanti in un modello di inquinamento voluttuario delle vie aeree (fumo di sigaretta). / Schiraldi, G. F.; Accinni, R.; Cetta, F.; Della Noce, C.; Caboni, G.; La Spina, T.; Allegra, L.

In: GIMT - Giornale Italiano delle Malattie del Torace, Vol. 62, No. 6, 2008, p. 375-381.

Research output: Contribution to journalArticle

Schiraldi, G. F. ; Accinni, R. ; Cetta, F. ; Della Noce, C. ; Caboni, G. ; La Spina, T. ; Allegra, L. / Markers per la valutazione dello stato redox dei tioli e dell'attività di antiossidanti in un modello di inquinamento voluttuario delle vie aeree (fumo di sigaretta). In: GIMT - Giornale Italiano delle Malattie del Torace. 2008 ; Vol. 62, No. 6. pp. 375-381.
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