Third trimester abdominal circumference, estimated fetal weight and uterine artery doppler for the identification of newborns small and large for gestational age

Giovanni Di Lorenzo, Lorenzo Monasta, Matteo Ceccarello, Vera Cecotti, Giuseppina D'Ottavio

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: To understand if ultrasound biometric evaluation at 30-32 weeks of gestation is a valuable screening tool for the detection of small-for-gestational-Age (SGA) and large-for-gestational-Age (LGA) infants at birth in a low risk population. Study design: We enrolled 1848 pregnant women with singleton pregnancy undergoing routine fetal biometry. We divided the infants into four groups: moderate SGA, severe SGA, moderate LGA and severe LGA. We considered third-trimester estimated fetal weight (EFW), abdominal circumference (AC), EFW centile (EFWc), AC centile (ACc) and compared their prediction toward SGA and LGA to determine which of these parameters was the best estimator for fetal size. Then we took the strongest predictive value and added all history-related and ultrasound factors to run a stepdown multivariate logistic regression. All the variables were then dichotomized and sensitivity models only for statistically significant parameters were calculated. Results: We identified the following predictive factors for each outcome: for severe SGA: EFWc with p <0.001, uterine artery pulsatility index (UtA PI) with p <0.002. For moderate SGA: EFWc with p <0.001, UtA PI with p <0.004, maternal preeclampsia p <0.002. For moderate and severe LGA: EFWc with p <0.001. Conclusion: We can detect in a low-risk population a group at risk of growth deviations. Adding Doppler velocimetry to 30-32 weeks EFWc improves the specificity (84%) regarding SGA newborns, maintaining a good sensitivity (71%), and reducing the population to be re-screened from 27 to 17%. An ultrasound examination at 34-36 weeks or the clinical assessment of maternal risk factors remain the best tools for LGA newborns.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume166
Issue number2
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Uterine Artery
Fetal Weight
Third Pregnancy Trimester
Gestational Age
Newborn Infant
Mothers
Biometry
Pregnancy
Rheology
Pre-Eclampsia
Population Groups
Population
Pregnant Women

Keywords

  • Estimated fetal weight
  • Fetal biometry
  • LGA
  • Preeclampsia
  • SGA
  • Uterine artery Doppler

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Third trimester abdominal circumference, estimated fetal weight and uterine artery doppler for the identification of newborns small and large for gestational age. / Di Lorenzo, Giovanni; Monasta, Lorenzo; Ceccarello, Matteo; Cecotti, Vera; D'Ottavio, Giuseppina.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 166, No. 2, 02.2013, p. 133-138.

Research output: Contribution to journalArticle

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abstract = "Objective: To understand if ultrasound biometric evaluation at 30-32 weeks of gestation is a valuable screening tool for the detection of small-for-gestational-Age (SGA) and large-for-gestational-Age (LGA) infants at birth in a low risk population. Study design: We enrolled 1848 pregnant women with singleton pregnancy undergoing routine fetal biometry. We divided the infants into four groups: moderate SGA, severe SGA, moderate LGA and severe LGA. We considered third-trimester estimated fetal weight (EFW), abdominal circumference (AC), EFW centile (EFWc), AC centile (ACc) and compared their prediction toward SGA and LGA to determine which of these parameters was the best estimator for fetal size. Then we took the strongest predictive value and added all history-related and ultrasound factors to run a stepdown multivariate logistic regression. All the variables were then dichotomized and sensitivity models only for statistically significant parameters were calculated. Results: We identified the following predictive factors for each outcome: for severe SGA: EFWc with p <0.001, uterine artery pulsatility index (UtA PI) with p <0.002. For moderate SGA: EFWc with p <0.001, UtA PI with p <0.004, maternal preeclampsia p <0.002. For moderate and severe LGA: EFWc with p <0.001. Conclusion: We can detect in a low-risk population a group at risk of growth deviations. Adding Doppler velocimetry to 30-32 weeks EFWc improves the specificity (84{\%}) regarding SGA newborns, maintaining a good sensitivity (71{\%}), and reducing the population to be re-screened from 27 to 17{\%}. An ultrasound examination at 34-36 weeks or the clinical assessment of maternal risk factors remain the best tools for LGA newborns.",
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AU - Cecotti, Vera

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