Three cases of bone metastases in patients with gastrointestinal stromal tumors

Valerio di Scioscio, Laura Greco, Maria Caterina Pallotti, Maria Abbondanza Pantaleo, Alessandra Maleddu, Margherita Nannini, Alberto Bazzocchi, Monica di Battista, Anna Mandrioli, Cristian Lolli, Maristella Saponara, Garzillo Giorgio, Guido Biasco, Maurizio Zompatori

Research output: Contribution to journalArticlepeer-review


Gastrointestinal stromal tumors (GISTs) are rare, but represent the most common mes-enchymal neoplasms of the gastrointestinal tract. Tumor resection is the treatment of choice for localized disease. Tyrosine kinase inhibitors (imatinib, sunitinib) are the standard therapy for metastatic or unresectable GISTs. GISTs usually metastasize to the liver and peritoneum. Bone metastases are uncommon. We describe three cases of bone metas-tases in patients with advanced GISTs: two women (82 and 54 years of age), and one man (62 years of age). Bones metastases involved the spine, pelvis and ribs in one patient, multiple vertebral bodies and pelvis in one, and the spine and iliac wings in the third case. The lesions presented a lytic pattern in all cases. Two patients presented with multiple bone metastases at the time of initial diagnosis and one patient after seven years during the follow-up period. This report describes the diagnosis and treatment of the lesions and may help clinicians to manage bones metastases in GIST patients.

Original languageEnglish
Pages (from-to)51-53
Number of pages3
JournalRare Tumors
Issue number2
Publication statusPublished - 2011


  • Bone metastases
  • Computerezed tomografy
  • Gastrointestinal stromal tumors
  • Imatinib
  • Scan

ASJC Scopus subject areas

  • Oncology
  • Histology


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