Three consecutive related bone marrow transplants for juvenile myelomonocytic leukaemia

Maura Faraci, Concetta Micalizzi, Edoardo Lanino, Francesca Scuderi, Giuseppe Morreale, Giorgio Dini, Barbara Cappelli, Sandro Dallorso

Research output: Contribution to journalArticlepeer-review

Abstract

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is the only cure for juvenile myelomonocytic leukaemia (JMML), but relapse remains the major cause of failure. A second transplant may be considered a way to induce the graft vs. leukaemia effect in patients who relapse after their first HSCT. We describe a 7-month-old girl with JMML who relapsed after a first, related allo-HSCT, and who again relapsed 8 months after the second transplant, despite discontinuation of immusuppressive therapy. She underwent a third allogeneic transplant from another related donor. At the time of this report the patient is in complete remission 26 months after the third transplant. We suggest that a third allo-HSCT may be taken into consideration for JMML patients who experience relapse, even after two previous transplants.

Original languageEnglish
Pages (from-to)797-800
Number of pages4
JournalPediatric Transplantation
Volume9
Issue number6
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Haematopoietic stem cell transplantation
  • Juvenile myelomonocytic leukaemia
  • Relapse

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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