TY - JOUR
T1 - Three different synchronous primary lung tumours
T2 - A case report with extensive genetic analysis and review of the literature
AU - Froio, Elisabetta
AU - D'Adda, Tiziana
AU - Fellegara, Giovanni
AU - Ampollini, Luca
AU - Carbognani, Paolo
AU - Rindi, Guido
PY - 2008/3
Y1 - 2008/3
N2 - Synchronous triple lung tumours are rare and little is known as for their genetic basis. Here we report a case of a 59 years old male with three synchronous independent and histological different primary tumours of the left lung. Two nodules were located in the upper lobe and consisted of an adenocarcinoma (ADC) and an endobronchial poorly differentiated squamous cell carcinoma (SCC). A third nodule of the lower lobe corresponded to a small cell neuroendocrine carcinoma (SCLC). To assess if they represented independent primary tumours and have common genetic profiles, tumours were investigated for loss of heterozygosity (LOH) at 40 chromosomal markers. A comparable fractional allelic loss of 0.52 was observed in the ADC and SCLC, while it was 0.28 in the SCC. Microallelotyping analysis did not reveal a common genetic profile, supporting the hypothesis that the three synchronous tumours are truly independent primaries with different histogenesis.
AB - Synchronous triple lung tumours are rare and little is known as for their genetic basis. Here we report a case of a 59 years old male with three synchronous independent and histological different primary tumours of the left lung. Two nodules were located in the upper lobe and consisted of an adenocarcinoma (ADC) and an endobronchial poorly differentiated squamous cell carcinoma (SCC). A third nodule of the lower lobe corresponded to a small cell neuroendocrine carcinoma (SCLC). To assess if they represented independent primary tumours and have common genetic profiles, tumours were investigated for loss of heterozygosity (LOH) at 40 chromosomal markers. A comparable fractional allelic loss of 0.52 was observed in the ADC and SCLC, while it was 0.28 in the SCC. Microallelotyping analysis did not reveal a common genetic profile, supporting the hypothesis that the three synchronous tumours are truly independent primaries with different histogenesis.
KW - Adenocarcinoma
KW - Loss of heterozygosity
KW - Lung
KW - Small cell neuroendocrine carcinoma
KW - Squamous cell carcinoma
KW - Synchronous tumours
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U2 - 10.1016/j.lungcan.2007.07.007
DO - 10.1016/j.lungcan.2007.07.007
M3 - Article
C2 - 17707945
AN - SCOPUS:40249116822
VL - 59
SP - 395
EP - 402
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
IS - 3
ER -