Three different synchronous primary lung tumours: A case report with extensive genetic analysis and review of the literature

Elisabetta Froio, Tiziana D'Adda, Giovanni Fellegara, Luca Ampollini, Paolo Carbognani, Guido Rindi

Research output: Contribution to journalArticlepeer-review

Abstract

Synchronous triple lung tumours are rare and little is known as for their genetic basis. Here we report a case of a 59 years old male with three synchronous independent and histological different primary tumours of the left lung. Two nodules were located in the upper lobe and consisted of an adenocarcinoma (ADC) and an endobronchial poorly differentiated squamous cell carcinoma (SCC). A third nodule of the lower lobe corresponded to a small cell neuroendocrine carcinoma (SCLC). To assess if they represented independent primary tumours and have common genetic profiles, tumours were investigated for loss of heterozygosity (LOH) at 40 chromosomal markers. A comparable fractional allelic loss of 0.52 was observed in the ADC and SCLC, while it was 0.28 in the SCC. Microallelotyping analysis did not reveal a common genetic profile, supporting the hypothesis that the three synchronous tumours are truly independent primaries with different histogenesis.

Original languageEnglish
Pages (from-to)395-402
Number of pages8
JournalLung Cancer
Volume59
Issue number3
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Adenocarcinoma
  • Loss of heterozygosity
  • Lung
  • Small cell neuroendocrine carcinoma
  • Squamous cell carcinoma
  • Synchronous tumours

ASJC Scopus subject areas

  • Oncology

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