Abstract
Cartilage lesions fail to heal spontaneously, leading to the development of chronic conditions which worsen the life quality of patients. Three-dimensional scaffold-based bioprinting holds the potential of tissue regeneration through the creation of organized, living constructs via a "layer-by-layer" deposition of small units of biomaterials and cells. This technique displays important advantages to mimic natural cartilage over traditional methods by allowing a fine control of cell distribution, and the modulation of mechanical and chemical properties. This opens up a number of new perspectives including personalized medicine through the development of complex structures (the osteochondral compartment), different types of cartilage (hyaline, fibrous), and constructs according to a specific patient's needs. However, the choice of the ideal combination of biomaterials and cells for cartilage bioprinting is still a challenge. Stem cells may improve material mimicry ability thanks to their unique properties: the immune-privileged status and the paracrine activity. Here, we review the recent advances in cartilage three-dimensional, scaffold-based bioprinting using stem cells and identify future developments for clinical translation. Database search terms used to write this review were: "articular cartilage", "menisci", "3D bioprinting", "bioinks", "stem cells", and "cartilage tissue engineering".
| Original language | English |
|---|---|
| Article number | 1749 |
| Pages (from-to) | 1-20 |
| Number of pages | 20 |
| Journal | Materials |
| Volume | 11 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 17 2018 |
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Keywords
- 3D bioprinting
- 4D printing
- Bioink
- Biomaterials
- Cartilage
- Meniscus
- Organ-on-a-chip
- Osteoarthritis
- Stem cells
ASJC Scopus subject areas
- Materials Science(all)
Cite this
Three-dimensional bioprinting of cartilage by the use of stem cells: A strategy to improve regeneration. / Roseti, Livia; Cavallo, Carola; Desando, Giovanna; Parisi, Valentina; Petretta, Mauro; Bartolotti, Isabella; Grigolo, Brunella.
In: Materials, Vol. 11, No. 9, 1749, 17.09.2018, p. 1-20.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Three-dimensional bioprinting of cartilage by the use of stem cells: A strategy to improve regeneration
AU - Roseti, Livia
AU - Cavallo, Carola
AU - Desando, Giovanna
AU - Parisi, Valentina
AU - Petretta, Mauro
AU - Bartolotti, Isabella
AU - Grigolo, Brunella
PY - 2018/9/17
Y1 - 2018/9/17
N2 - Cartilage lesions fail to heal spontaneously, leading to the development of chronic conditions which worsen the life quality of patients. Three-dimensional scaffold-based bioprinting holds the potential of tissue regeneration through the creation of organized, living constructs via a "layer-by-layer" deposition of small units of biomaterials and cells. This technique displays important advantages to mimic natural cartilage over traditional methods by allowing a fine control of cell distribution, and the modulation of mechanical and chemical properties. This opens up a number of new perspectives including personalized medicine through the development of complex structures (the osteochondral compartment), different types of cartilage (hyaline, fibrous), and constructs according to a specific patient's needs. However, the choice of the ideal combination of biomaterials and cells for cartilage bioprinting is still a challenge. Stem cells may improve material mimicry ability thanks to their unique properties: the immune-privileged status and the paracrine activity. Here, we review the recent advances in cartilage three-dimensional, scaffold-based bioprinting using stem cells and identify future developments for clinical translation. Database search terms used to write this review were: "articular cartilage", "menisci", "3D bioprinting", "bioinks", "stem cells", and "cartilage tissue engineering".
AB - Cartilage lesions fail to heal spontaneously, leading to the development of chronic conditions which worsen the life quality of patients. Three-dimensional scaffold-based bioprinting holds the potential of tissue regeneration through the creation of organized, living constructs via a "layer-by-layer" deposition of small units of biomaterials and cells. This technique displays important advantages to mimic natural cartilage over traditional methods by allowing a fine control of cell distribution, and the modulation of mechanical and chemical properties. This opens up a number of new perspectives including personalized medicine through the development of complex structures (the osteochondral compartment), different types of cartilage (hyaline, fibrous), and constructs according to a specific patient's needs. However, the choice of the ideal combination of biomaterials and cells for cartilage bioprinting is still a challenge. Stem cells may improve material mimicry ability thanks to their unique properties: the immune-privileged status and the paracrine activity. Here, we review the recent advances in cartilage three-dimensional, scaffold-based bioprinting using stem cells and identify future developments for clinical translation. Database search terms used to write this review were: "articular cartilage", "menisci", "3D bioprinting", "bioinks", "stem cells", and "cartilage tissue engineering".
KW - 3D bioprinting
KW - 4D printing
KW - Bioink
KW - Biomaterials
KW - Cartilage
KW - Meniscus
KW - Organ-on-a-chip
KW - Osteoarthritis
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=85053404868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053404868&partnerID=8YFLogxK
U2 - 10.3390/ma11091749
DO - 10.3390/ma11091749
M3 - Review article
AN - SCOPUS:85053404868
VL - 11
SP - 1
EP - 20
JO - Materials
JF - Materials
SN - 1996-1944
IS - 9
M1 - 1749
ER -