TY - JOUR
T1 - Three-dimensional conformal or stereotactic reirradiation of recurrent, metastatic or new primary tumors
T2 - Analysis of 108 patients
AU - Jereczek-Fossa, Barbara A.
AU - Kowalczyk, Anna
AU - D'Onofrio, Alberto
AU - Catalano, Gianpiero
AU - Garibaldi, Cristina
AU - Boboc, Genoveva
AU - Vitolo, Viviana
AU - Leonardi, Maria Cristina
AU - Cambria, Raffaella
AU - Orecchia, Roberto
PY - 2008/1
Y1 - 2008/1
N2 - Purpose: To analyze the outcome of reirradiation of recurrent/metastatic or new primary tumors with three-dimensional conformal (3D-CRT) or stereotactic (SRT) techniques. Patients and Methods: 108 patients reirradiated between 01/2002 and 01/2005 at the European Institute of Oncology, Milan, Italy, were analyzed. Primary diagnosis included breast, lung, head/neck, urologic tumors, and other primaries. Curative and palliative intent were applied to 27 (25%) and 81 patients (75%), respectively. 3D-CRT and SRT were employed in 57 (53%) and 48 patients (44%), respectively, up to a mean dose of 23 Gy. Results: Median follow-up was 7 months (range, 1-50 months). Response, stabilization, and progression were observed in 33%, 36%, and 17% of patients, respectively (15 patients were not evaluable). No severe toxicity was reported. Median overall survival amounted to 32.6 months and was longer in patients treated with curative intent. Conclusion: A small portion of patients can be cured with a second course of radiotherapy, and in many cases, palliation can be obtained. Low toxicity of reirradiation with use of modern techniques should allow for the delivery of higher doses and, in consequence, lead to an improvement in reirradiation outcome.
AB - Purpose: To analyze the outcome of reirradiation of recurrent/metastatic or new primary tumors with three-dimensional conformal (3D-CRT) or stereotactic (SRT) techniques. Patients and Methods: 108 patients reirradiated between 01/2002 and 01/2005 at the European Institute of Oncology, Milan, Italy, were analyzed. Primary diagnosis included breast, lung, head/neck, urologic tumors, and other primaries. Curative and palliative intent were applied to 27 (25%) and 81 patients (75%), respectively. 3D-CRT and SRT were employed in 57 (53%) and 48 patients (44%), respectively, up to a mean dose of 23 Gy. Results: Median follow-up was 7 months (range, 1-50 months). Response, stabilization, and progression were observed in 33%, 36%, and 17% of patients, respectively (15 patients were not evaluable). No severe toxicity was reported. Median overall survival amounted to 32.6 months and was longer in patients treated with curative intent. Conclusion: A small portion of patients can be cured with a second course of radiotherapy, and in many cases, palliation can be obtained. Low toxicity of reirradiation with use of modern techniques should allow for the delivery of higher doses and, in consequence, lead to an improvement in reirradiation outcome.
KW - Recurrent
KW - Reirradiation
KW - Retreatment
KW - Second primary
KW - Second-course radiotherapy
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U2 - 10.1007/s00066-008-1783-9
DO - 10.1007/s00066-008-1783-9
M3 - Article
C2 - 18188521
AN - SCOPUS:38149128170
VL - 184
SP - 36
EP - 40
JO - Strahlentherapie und Onkologie
JF - Strahlentherapie und Onkologie
SN - 0179-7158
IS - 1
ER -