Three-dimensional MRI perfusion maps: A step beyond volumetric analysis in mental disorders

Paolo F. Fabene, Paolo Farace, Paolo Brambilla, Nicola Andreone, Roberto Cerini, Luisa Pelizza, Amelia Versace, Gianluca Rambaldelli, Niels Birbaumer, Michele Tansella, Andrea Sbarbati

Research output: Contribution to journalArticle

Abstract

A new type of magnetic resonance imaging analysis, based on fusion of three-dimensional reconstructions of time-to-peak parametric maps and high-resolution T1-weighted images, is proposed in order to evaluate the perfusion of selected volumes of interest. Because in recent years a wealth of data have suggested the crucial involvement of vascular alterations in mental diseases, we tested our new method on a restricted sample of schizophrenic patients and matched healthy controls. The perfusion of the whole brain was compared with that of the caudate nucleus by means of intrasubject analysis. As expected, owing to the encephalic vascular pattern, a significantly lower time-to-peak was observed in the caudate nucleus than in the whole brain in all healthy controls, indicating that the suggested method has enough sensitivity to detect subtle perfusion changes even in small volumes of interest. Interestingly, a less uniform pattern was observed in the schizophrenic patients. The latter finding needs to be replicated in an adequate number of subjects. In summary, the three-dimensional analysis method we propose has been shown to be a feasible tool for revealing subtle vascular changes both in normal subjects and in pathological conditions.

Original languageEnglish
Pages (from-to)122-128
Number of pages7
JournalJournal of Anatomy
Volume210
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Brain perfusion
  • Gadolinium
  • Schizophrenia
  • Segmentation
  • Time-to-peak

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Fingerprint Dive into the research topics of 'Three-dimensional MRI perfusion maps: A step beyond volumetric analysis in mental disorders'. Together they form a unique fingerprint.

  • Cite this

    Fabene, P. F., Farace, P., Brambilla, P., Andreone, N., Cerini, R., Pelizza, L., Versace, A., Rambaldelli, G., Birbaumer, N., Tansella, M., & Sbarbati, A. (2007). Three-dimensional MRI perfusion maps: A step beyond volumetric analysis in mental disorders. Journal of Anatomy, 210(1), 122-128. https://doi.org/10.1111/j.1469-7580.2006.00659.x