Three-dimensional structure of the α-MSH-derived candidacidal peptide [Ac-CKPV]2

A. Catania, P. Grieco, A. Randazzo, E. Novellino, S. Gatti, C. Rossi, G. Colombo, J. M. Lipton

Research output: Contribution to journalArticlepeer-review

Abstract

Previous research has shown that the immunomodulatory peptide α-melanocyte-stimulating hormone (α-MSH) and its carboxy-terminal tripeptide KPV (Lys-Pro-Val α-MSH11-13) have antimicrobial influences. By inserting a Cys-Cys linker between two units of KPV, we designed the dimer [Ac-CKPV]2 that showed excellent candidacidal effects in pilot tests and was the subject of further investigations. [Ac-CKPV]2 was active against azole-resistant Candida spp. Therefore, the molecule appeared a promising candidate for therapy of fungal infections and was the subject of a structural study. 1H-NMR and restrained mechanic and dynamic calculations suggest that the peptide adopts an extended backbone structure with a β-turn-like structure. These results open a pathway to development of additional novel compounds that have candidacidal effects potentially useful against clinical infections. Copyright Blackwell Munksgaard, 2005.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalJournal of Peptide Research
Volume66
Issue number1
DOIs
Publication statusPublished - Jul 2005

Keywords

  • α-melanocyte-stimulating hormone
  • Antimicrobial peptides
  • Candida species
  • Nuclear magnetic resonance
  • Yeast infections

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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