Three discrete regions of deletion at 3p in head and neck cancers

Roberta Maestro, Daniela Gasparotto, Tamara Vukosavljevic, Luigi Barzan, Sandro Sulfaro, Mauro Boiocchi

Research output: Contribution to journalArticlepeer-review

Abstract

Alteration of the short arm of chromosome 3 is one of the most consistent cytogenetic abnormalities found in human head and neck cancers. These alterations, composed of translocations and deletions, have been associated with the presence of a tumor suppressor gene(s), but no clear evidence of the location of this presumptive gene(s) was available. We performed a molecular analysis of the 3p region using a polymerase chain reaction-based approach. Twenty-eight of the 38 cases analyzed (74%) showed the presence of single or multiple areas of allelic loss. Three commonly deleted regions, tentatively mapped to 3p24-ter, 3p21.3, and 3p14-cen, were identified. Our results suggest that at least three oncosuppressor genes mapping on 3p may be involved in head and neck cancer development and support a common oncogenicc pathway with squamous cell lung cancer, for which a similar pattern of 3p deletion has been described recently.

Original languageEnglish
Pages (from-to)5775-5779
Number of pages5
JournalCancer Research
Volume53
Issue number23
Publication statusPublished - Dec 1 1993

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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