Three discrete regions of deletion at 3p in head and neck cancers

Roberta Maestro, Daniela Gasparotto, Tamara Vukosavljevic, Luigi Barzan, Sandro Sulfaro, Mauro Boiocchi

Research output: Contribution to journalArticle

Abstract

Alteration of the short arm of chromosome 3 is one of the most consistent cytogenetic abnormalities found in human head and neck cancers. These alterations, composed of translocations and deletions, have been associated with the presence of a tumor suppressor gene(s), but no clear evidence of the location of this presumptive gene(s) was available. We performed a molecular analysis of the 3p region using a polymerase chain reaction-based approach. Twenty-eight of the 38 cases analyzed (74%) showed the presence of single or multiple areas of allelic loss. Three commonly deleted regions, tentatively mapped to 3p24-ter, 3p21.3, and 3p14-cen, were identified. Our results suggest that at least three oncosuppressor genes mapping on 3p may be involved in head and neck cancer development and support a common oncogenicc pathway with squamous cell lung cancer, for which a similar pattern of 3p deletion has been described recently.

Original languageEnglish
Pages (from-to)5775-5779
Number of pages5
JournalCancer Research
Volume53
Issue number23
Publication statusPublished - Dec 1 1993

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Head and Neck Neoplasms
Squamous Cell Neoplasms
Chromosomes, Human, Pair 3
Loss of Heterozygosity
Chromosome Mapping
Tumor Suppressor Genes
Chromosome Aberrations
Lung Neoplasms
Polymerase Chain Reaction
Genes
Monosomy 3p Chromosome 3

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Maestro, R., Gasparotto, D., Vukosavljevic, T., Barzan, L., Sulfaro, S., & Boiocchi, M. (1993). Three discrete regions of deletion at 3p in head and neck cancers. Cancer Research, 53(23), 5775-5779.

Three discrete regions of deletion at 3p in head and neck cancers. / Maestro, Roberta; Gasparotto, Daniela; Vukosavljevic, Tamara; Barzan, Luigi; Sulfaro, Sandro; Boiocchi, Mauro.

In: Cancer Research, Vol. 53, No. 23, 01.12.1993, p. 5775-5779.

Research output: Contribution to journalArticle

Maestro, R, Gasparotto, D, Vukosavljevic, T, Barzan, L, Sulfaro, S & Boiocchi, M 1993, 'Three discrete regions of deletion at 3p in head and neck cancers', Cancer Research, vol. 53, no. 23, pp. 5775-5779.
Maestro R, Gasparotto D, Vukosavljevic T, Barzan L, Sulfaro S, Boiocchi M. Three discrete regions of deletion at 3p in head and neck cancers. Cancer Research. 1993 Dec 1;53(23):5775-5779.
Maestro, Roberta ; Gasparotto, Daniela ; Vukosavljevic, Tamara ; Barzan, Luigi ; Sulfaro, Sandro ; Boiocchi, Mauro. / Three discrete regions of deletion at 3p in head and neck cancers. In: Cancer Research. 1993 ; Vol. 53, No. 23. pp. 5775-5779.
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