Abstract
Alteration of the short arm of chromosome 3 is one of the most consistent cytogenetic abnormalities found in human head and neck cancers. These alterations, composed of translocations and deletions, have been associated with the presence of a tumor suppressor gene(s), but no clear evidence of the location of this presumptive gene(s) was available. We performed a molecular analysis of the 3p region using a polymerase chain reaction-based approach. Twenty-eight of the 38 cases analyzed (74%) showed the presence of single or multiple areas of allelic loss. Three commonly deleted regions, tentatively mapped to 3p24-ter, 3p21.3, and 3p14-cen, were identified. Our results suggest that at least three oncosuppressor genes mapping on 3p may be involved in head and neck cancer development and support a common oncogenicc pathway with squamous cell lung cancer, for which a similar pattern of 3p deletion has been described recently.
| Original language | English |
|---|---|
| Pages (from-to) | 5775-5779 |
| Number of pages | 5 |
| Journal | Cancer Research |
| Volume | 53 |
| Issue number | 23 |
| Publication status | Published - Dec 1 1993 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Three discrete regions of deletion at 3p in head and neck cancers. / Maestro, Roberta; Gasparotto, Daniela; Vukosavljevic, Tamara; Barzan, Luigi; Sulfaro, Sandro; Boiocchi, Mauro.
In: Cancer Research, Vol. 53, No. 23, 01.12.1993, p. 5775-5779.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Three discrete regions of deletion at 3p in head and neck cancers
AU - Maestro, Roberta
AU - Gasparotto, Daniela
AU - Vukosavljevic, Tamara
AU - Barzan, Luigi
AU - Sulfaro, Sandro
AU - Boiocchi, Mauro
PY - 1993/12/1
Y1 - 1993/12/1
N2 - Alteration of the short arm of chromosome 3 is one of the most consistent cytogenetic abnormalities found in human head and neck cancers. These alterations, composed of translocations and deletions, have been associated with the presence of a tumor suppressor gene(s), but no clear evidence of the location of this presumptive gene(s) was available. We performed a molecular analysis of the 3p region using a polymerase chain reaction-based approach. Twenty-eight of the 38 cases analyzed (74%) showed the presence of single or multiple areas of allelic loss. Three commonly deleted regions, tentatively mapped to 3p24-ter, 3p21.3, and 3p14-cen, were identified. Our results suggest that at least three oncosuppressor genes mapping on 3p may be involved in head and neck cancer development and support a common oncogenicc pathway with squamous cell lung cancer, for which a similar pattern of 3p deletion has been described recently.
AB - Alteration of the short arm of chromosome 3 is one of the most consistent cytogenetic abnormalities found in human head and neck cancers. These alterations, composed of translocations and deletions, have been associated with the presence of a tumor suppressor gene(s), but no clear evidence of the location of this presumptive gene(s) was available. We performed a molecular analysis of the 3p region using a polymerase chain reaction-based approach. Twenty-eight of the 38 cases analyzed (74%) showed the presence of single or multiple areas of allelic loss. Three commonly deleted regions, tentatively mapped to 3p24-ter, 3p21.3, and 3p14-cen, were identified. Our results suggest that at least three oncosuppressor genes mapping on 3p may be involved in head and neck cancer development and support a common oncogenicc pathway with squamous cell lung cancer, for which a similar pattern of 3p deletion has been described recently.
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M3 - Article
C2 - 8242635
AN - SCOPUS:0027453998
VL - 53
SP - 5775
EP - 5779
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 23
ER -