Three novel alleles at the HLA-DRB1 locus identified by sequence-based typing

Sara Frison; Elena Longhi; Martina Mantovani; Monica Mantia; Cinzia Tagliaferri; Daniela Di Giorgio; Mario Scalamogna; Francesca Poli

doi:10.1016/j.humimm.2011.11.004

Three novel alleles at the HLA-DRB1 locus identified by sequence-based typing

Sara Frison, Elena Longhi, Martina Mantovani, Monica Mantia, Cinzia Tagliaferri, Daniela Di Giorgio, Mario Scalamogna, Francesca Poli

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

We describe here the sequences of 3 new HLA-DRB1 variants officially named DRB1*03:05:03, DRB1*11:10:02, and DRB1*14:86. These novel alleles have been detected in 3 Caucasoid individuals by sequence-based typing. The first and second alleles are the result of a silent mutation, which does not imply any amino acid change. The sequence of DRB1*14:86 exhibits a single nucleotide difference with the allele DRB1*14:01:01 at position 239.

Original language	English
Pages (from-to)	67-69
Number of pages	3
Journal	Human Immunology
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/j.humimm.2011.11.004
Publication status	Published - Jan 2012

Keywords

HLA-DRB1*03:05:03
HLA-DRB1*11:10:02
HLA-DRB1*14:86
SBT

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/j.humimm.2011.11.004

Cite this

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title = "Three novel alleles at the HLA-DRB1 locus identified by sequence-based typing",

abstract = "We describe here the sequences of 3 new HLA-DRB1 variants officially named DRB1*03:05:03, DRB1*11:10:02, and DRB1*14:86. These novel alleles have been detected in 3 Caucasoid individuals by sequence-based typing. The first and second alleles are the result of a silent mutation, which does not imply any amino acid change. The sequence of DRB1*14:86 exhibits a single nucleotide difference with the allele DRB1*14:01:01 at position 239.",

keywords = "HLA-DRB1*03:05:03, HLA-DRB1*11:10:02, HLA-DRB1*14:86, SBT",

author = "Sara Frison and Elena Longhi and Martina Mantovani and Monica Mantia and Cinzia Tagliaferri and {Di Giorgio}, Daniela and Mario Scalamogna and Francesca Poli",

year = "2012",

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AU - Frison, Sara

AU - Longhi, Elena

AU - Mantovani, Martina

AU - Mantia, Monica

AU - Tagliaferri, Cinzia

AU - Di Giorgio, Daniela

AU - Scalamogna, Mario

AU - Poli, Francesca

PY - 2012/1

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AB - We describe here the sequences of 3 new HLA-DRB1 variants officially named DRB1*03:05:03, DRB1*11:10:02, and DRB1*14:86. These novel alleles have been detected in 3 Caucasoid individuals by sequence-based typing. The first and second alleles are the result of a silent mutation, which does not imply any amino acid change. The sequence of DRB1*14:86 exhibits a single nucleotide difference with the allele DRB1*14:01:01 at position 239.

KW - HLA-DRB103:05:03

KW - HLA-DRB111:10:02

KW - HLA-DRB114:86

KW - SBT

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Three novel alleles at the HLA-DRB1 locus identified by sequence-based typing

Abstract

Keywords

ASJC Scopus subject areas

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