Three-year clinical outcome of percutaneous treatment of bifurcation lesions in multivessel coronary artery disease with the sirolimus-eluting stent: Insights from the Arterial Revascularisation Therapies Study, part II (ARTS II)

Helen C. Routledge, Thierry Lefèvre, Antonio Colombo, Keith G. Oldroyd, Christian W. Hamm, Giulio Guagliumi, Wolfgang von Scheidt, Victor Guetta, Witold Ruzyllo, Kristel Wittebols, Dick M. Goedhart, Patrick W. Serruys

Research output: Contribution to journalArticle

Abstract

Aims: The long-term impact of treating bifurcation lesions on the overall outcome of patients with multivessel coronary disease treated percutaneously with drug-eluting stents is unknown. This analysis determined the influence of bifurcation treatment using sirolimus-eluting stents on 3-year clinical outcomes. Methods and results: Of the 607 patients (2,160 lesions) in the ARTS II study, 324 patients underwent revascularisation procedures involving treatment of at least one bifurcation (465 lesions). Three-year outcomes were compared to those without bifurcations. Despite more diffuse and complex disease in the bifurcation group, survival free of adverse events was equivalent in the two groups. At 3-years, there was no difference in rate of overall MACCE (20.2% vs. 18.5%, p=NS) or any of the component events between the bifurcation and the non-bifurcation group. There was a trend for a higher rate of definite stent thrombosis in the bifurcation group (4.6 vs 2.1%, p=0.1), but in multivariate analysis the CK value post-procedure served as the only independent predictor of definite stent thrombosis (p=0.015), with the presence of a bifurcation lesion of borderline significance (p=0.056). Conclusions: In multivessel disease treated by PCI with DES, the presence of bifurcation disease had no adverse influence on 3-year clinical outcomes.

Original languageEnglish
Pages (from-to)190-196
Number of pages7
JournalEuroIntervention
Volume5
Issue number2
Publication statusPublished - 2009

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Keywords

  • Angioplasty
  • Sirolimus-eluting stent
  • Stent thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Routledge, H. C., Lefèvre, T., Colombo, A., Oldroyd, K. G., Hamm, C. W., Guagliumi, G., von Scheidt, W., Guetta, V., Ruzyllo, W., Wittebols, K., Goedhart, D. M., & Serruys, P. W. (2009). Three-year clinical outcome of percutaneous treatment of bifurcation lesions in multivessel coronary artery disease with the sirolimus-eluting stent: Insights from the Arterial Revascularisation Therapies Study, part II (ARTS II). EuroIntervention, 5(2), 190-196.