Three-year results after neoadjuvant chemotherapy, radical surgery, and radiotherapy in locally advanced cervical carcinoma

Gerardo Zanetta, Fabio Landoni, Alessandro Colombo, Antonio Pellegrino, Andrea Maneo, Chari Laos Leventis

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Abstract

Objective. To evaluate the complications and results of neoadjuvant treatment before surgery and radiotherapy in locally advanced cervical carcinoma. Methods: Between March 1988 and June 1989, 24 consecutive patients with locally advanced cervical carcinoma received chemotherapy consisting of six weekly courses of cisplatin (50 mg/m2), vincristine (1 mg/m2), and bleomycin (30 mg), followed by radical hysterectomy and radiotherapy. Lymph node metastases were detected by means of lymphangiography and confirmed by fine-needle aspiration in 21 patients. Results: Twenty-one women (87.5%) completed the planned sequence of treatment and 16 (66.7%) achieved objective responses. Three patients did not complete chemotherapy (one refusal, one myocardial infarction, one severe allergic reaction) and were treated further by radiotherapy. Nineteen subjects (79%) underwent subsequent radical surgery and radiotherapy without serious complications. After a minimal follow-up of 3 years, 16 patients had died of disease. Distant recurrences developed in only three of eight women in whom the nodes were negative originally, possibly reflecting systemic effectiveness of the chemotherapy. Conclusion: This sequence of treatment, although feasible, does not seem to improve long-term survival compared to standard treatment.

Original languageEnglish
Pages (from-to)447-450
Number of pages4
JournalObstetrics and Gynecology
Volume82
Issue number3
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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    Zanetta, G., Landoni, F., Colombo, A., Pellegrino, A., Maneo, A., & Leventis, C. L. (1993). Three-year results after neoadjuvant chemotherapy, radical surgery, and radiotherapy in locally advanced cervical carcinoma. Obstetrics and Gynecology, 82(3), 447-450.