Thrombin activation and late restenosis after percutaneous transluminal coronary angioplasty

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Abstract

Background: Mechanisms of restenosis after percutaneous transluminal coronary angioplasty (PTCA) have not been defined yet. Experimental studies have shown that thrombin, by stimulating platelet growth factor secretion and smooth muscle cell proliferation, can play a major role. Methods and Results: In 34 patients with single-vessel coronary disease undergoing PTCA, thrombin activity was evaluated through serial fibrinopeptide A (FPA) plasma determinations. Samples were performed before PTCA, immediately after 24 hours, 72 hours, and 6 months later. Patients were grouped according to the development (group 1, n = 13) or nondevelopment (group 2, n = 21) of restenosis at a 6-month angiographic control. No difference in the two groups was found concerning baseline FPA values. In patients in group 1, soon after PTCA higher FPA levels (27.3 ± 13.7 ng/ml) than those in group 2 (9.2 ± 5.6 ng/ml; p <0.05 vs pre-PTCA, and p <0.01 between the two groups) were observed. No differences in FPA levels were detected at the other steps between the two groups. Conclusion: Our data suggest that thrombin plays a role in the process of restenosis after PTCA; acute FPA response to the procedure seems to have a predictive value.

Original languageEnglish
Pages (from-to)503-509
Number of pages7
JournalAmerican Heart Journal
Volume135
Issue number3
DOIs
Publication statusPublished - 1998

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Coronary Balloon Angioplasty
Fibrinopeptide A
Thrombin
Smooth Muscle Myocytes
Coronary Disease
Intercellular Signaling Peptides and Proteins
Blood Platelets
Cell Proliferation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Thrombin activation and late restenosis after percutaneous transluminal coronary angioplasty",
abstract = "Background: Mechanisms of restenosis after percutaneous transluminal coronary angioplasty (PTCA) have not been defined yet. Experimental studies have shown that thrombin, by stimulating platelet growth factor secretion and smooth muscle cell proliferation, can play a major role. Methods and Results: In 34 patients with single-vessel coronary disease undergoing PTCA, thrombin activity was evaluated through serial fibrinopeptide A (FPA) plasma determinations. Samples were performed before PTCA, immediately after 24 hours, 72 hours, and 6 months later. Patients were grouped according to the development (group 1, n = 13) or nondevelopment (group 2, n = 21) of restenosis at a 6-month angiographic control. No difference in the two groups was found concerning baseline FPA values. In patients in group 1, soon after PTCA higher FPA levels (27.3 ± 13.7 ng/ml) than those in group 2 (9.2 ± 5.6 ng/ml; p <0.05 vs pre-PTCA, and p <0.01 between the two groups) were observed. No differences in FPA levels were detected at the other steps between the two groups. Conclusion: Our data suggest that thrombin plays a role in the process of restenosis after PTCA; acute FPA response to the procedure seems to have a predictive value.",
author = "A. Salvioni and S. Galli and G. Marenzi and G. Lauri and Perego, {G. B.} and E. Assanelli and Guazzi, {M. D.}",
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T1 - Thrombin activation and late restenosis after percutaneous transluminal coronary angioplasty

AU - Salvioni, A.

AU - Galli, S.

AU - Marenzi, G.

AU - Lauri, G.

AU - Perego, G. B.

AU - Assanelli, E.

AU - Guazzi, M. D.

PY - 1998

Y1 - 1998

N2 - Background: Mechanisms of restenosis after percutaneous transluminal coronary angioplasty (PTCA) have not been defined yet. Experimental studies have shown that thrombin, by stimulating platelet growth factor secretion and smooth muscle cell proliferation, can play a major role. Methods and Results: In 34 patients with single-vessel coronary disease undergoing PTCA, thrombin activity was evaluated through serial fibrinopeptide A (FPA) plasma determinations. Samples were performed before PTCA, immediately after 24 hours, 72 hours, and 6 months later. Patients were grouped according to the development (group 1, n = 13) or nondevelopment (group 2, n = 21) of restenosis at a 6-month angiographic control. No difference in the two groups was found concerning baseline FPA values. In patients in group 1, soon after PTCA higher FPA levels (27.3 ± 13.7 ng/ml) than those in group 2 (9.2 ± 5.6 ng/ml; p <0.05 vs pre-PTCA, and p <0.01 between the two groups) were observed. No differences in FPA levels were detected at the other steps between the two groups. Conclusion: Our data suggest that thrombin plays a role in the process of restenosis after PTCA; acute FPA response to the procedure seems to have a predictive value.

AB - Background: Mechanisms of restenosis after percutaneous transluminal coronary angioplasty (PTCA) have not been defined yet. Experimental studies have shown that thrombin, by stimulating platelet growth factor secretion and smooth muscle cell proliferation, can play a major role. Methods and Results: In 34 patients with single-vessel coronary disease undergoing PTCA, thrombin activity was evaluated through serial fibrinopeptide A (FPA) plasma determinations. Samples were performed before PTCA, immediately after 24 hours, 72 hours, and 6 months later. Patients were grouped according to the development (group 1, n = 13) or nondevelopment (group 2, n = 21) of restenosis at a 6-month angiographic control. No difference in the two groups was found concerning baseline FPA values. In patients in group 1, soon after PTCA higher FPA levels (27.3 ± 13.7 ng/ml) than those in group 2 (9.2 ± 5.6 ng/ml; p <0.05 vs pre-PTCA, and p <0.01 between the two groups) were observed. No differences in FPA levels were detected at the other steps between the two groups. Conclusion: Our data suggest that thrombin plays a role in the process of restenosis after PTCA; acute FPA response to the procedure seems to have a predictive value.

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