Thrombin and cancer: From molecular basis to therapeutic implications

Massimo Franchini, Piermannuccio Mannucci

Research output: Contribution to journalArticlepeer-review


The relationship between cancer and thrombosis has been recognized for nearly 150 years. Although the mechanisms underlying this association are not completely understood, there are increasing evidences suggesting a pivotal role of thrombin in cancer biology. This review will focus on the most important pathways by which thrombin may affect cancer growth and dissemination. In addition, the potential role of congenital (i.e., hemophilia) and pharmaceutical (i.e., antithrombotic agents) anticoagulation in cancer incidence and survival will be investigated through the analysis of the published experimental and clinical studies.

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalSeminars in Thrombosis and Hemostasis
Issue number1
Publication statusPublished - 2012


  • anticoagulant
  • cancer
  • hemophilia
  • thrombin

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine


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