Thrombin increases the adhesion of washed human platelets to collagen

F. Sinigaglia, C. L. Balduini, A. Bisio, C. Balduini

Research output: Contribution to journalArticle

Abstract

Thrombin stimulates the adhesion of washed human platelets to fibrillar collagen. This phenomenon occurs also when platelets, before thrombin stimulation, are resuspended in the presence of prostaglandin E 1 to minimize the release reaction. Enzymatic activity of thrombin is not necessary for the enhancement of platelet adhesiveness, since phenylmethylsulphonylfluoride inhibited thrombin is effective in this respect. Detachment of thrombin from thrombin treated platelets by the use of hirudin restores normal platelet adhesiveness to collagen.

Original languageEnglish
Pages (from-to)587-592
Number of pages6
JournalBritish Journal of Haematology
Volume59
Issue number4
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Hematology

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