Abstract
Background: Platelets are inflammatory cells with an important role in antimicrobial host defenses. We speculate that an abnormal platelet count may be a marker of severity in patients with community-acquired pneumonia (CAP). The objectives of this study were to evaluate if abnormal platelet count in hospitalized patients with CAP was associated with 30-day mortality and to compare platelet count and leukocyte count as predictors of 30-day mortality. Methods: We performed a retrospective cohort study of 500 consecutive patients hospitalized with CAP at the Veterans Hospital of Louisville, Kentucky, between June 2001 and March 2006 to investigate the association of platelet count and leukocyte count with 30-day mortality. Predictor variables were platelet count and leukocyte count. Abnormal platelet count was <100,000/L (thrombocytopenia) and > 400,000/L (thrombocytosis). The outcome variable was 30-day mortality. To control for potential confounding, a propensity score that incorporated 33 variables was used. Results: Platelet count was strongly associated ( P = .0009) with 30-day mortality, whereas no association was observed for leukocyte count ( P = .5114). High platelet counts resulted in a significantly increased risk of mortality. Conclusions: Thrombocytopenia and thrombocytosis are associated with mortality in patients hospitalized with CAP. When evaluating an initial CBC test in patients with CAP, an abnormal platelet count is a better predictor of outcome than an abnormal leukocyte count.
| Original language | English |
|---|---|
| Pages (from-to) | 416-420 |
| Number of pages | 5 |
| Journal | Chest |
| Volume | 137 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2010 |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine
- Cardiology and Cardiovascular Medicine
Cite this
Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia. / Mirsaeidi, Mehdi; Peyrani, Paula; Aliberti, Stefano; Filardo, Giovanni; Bordon, Jose; Blasi, Francesco; Ramirez, Julio A.
In: Chest, Vol. 137, No. 2, 01.02.2010, p. 416-420.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia
AU - Mirsaeidi, Mehdi
AU - Peyrani, Paula
AU - Aliberti, Stefano
AU - Filardo, Giovanni
AU - Bordon, Jose
AU - Blasi, Francesco
AU - Ramirez, Julio A.
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Background: Platelets are inflammatory cells with an important role in antimicrobial host defenses. We speculate that an abnormal platelet count may be a marker of severity in patients with community-acquired pneumonia (CAP). The objectives of this study were to evaluate if abnormal platelet count in hospitalized patients with CAP was associated with 30-day mortality and to compare platelet count and leukocyte count as predictors of 30-day mortality. Methods: We performed a retrospective cohort study of 500 consecutive patients hospitalized with CAP at the Veterans Hospital of Louisville, Kentucky, between June 2001 and March 2006 to investigate the association of platelet count and leukocyte count with 30-day mortality. Predictor variables were platelet count and leukocyte count. Abnormal platelet count was <100,000/L (thrombocytopenia) and > 400,000/L (thrombocytosis). The outcome variable was 30-day mortality. To control for potential confounding, a propensity score that incorporated 33 variables was used. Results: Platelet count was strongly associated ( P = .0009) with 30-day mortality, whereas no association was observed for leukocyte count ( P = .5114). High platelet counts resulted in a significantly increased risk of mortality. Conclusions: Thrombocytopenia and thrombocytosis are associated with mortality in patients hospitalized with CAP. When evaluating an initial CBC test in patients with CAP, an abnormal platelet count is a better predictor of outcome than an abnormal leukocyte count.
AB - Background: Platelets are inflammatory cells with an important role in antimicrobial host defenses. We speculate that an abnormal platelet count may be a marker of severity in patients with community-acquired pneumonia (CAP). The objectives of this study were to evaluate if abnormal platelet count in hospitalized patients with CAP was associated with 30-day mortality and to compare platelet count and leukocyte count as predictors of 30-day mortality. Methods: We performed a retrospective cohort study of 500 consecutive patients hospitalized with CAP at the Veterans Hospital of Louisville, Kentucky, between June 2001 and March 2006 to investigate the association of platelet count and leukocyte count with 30-day mortality. Predictor variables were platelet count and leukocyte count. Abnormal platelet count was <100,000/L (thrombocytopenia) and > 400,000/L (thrombocytosis). The outcome variable was 30-day mortality. To control for potential confounding, a propensity score that incorporated 33 variables was used. Results: Platelet count was strongly associated ( P = .0009) with 30-day mortality, whereas no association was observed for leukocyte count ( P = .5114). High platelet counts resulted in a significantly increased risk of mortality. Conclusions: Thrombocytopenia and thrombocytosis are associated with mortality in patients hospitalized with CAP. When evaluating an initial CBC test in patients with CAP, an abnormal platelet count is a better predictor of outcome than an abnormal leukocyte count.
UR - http://www.scopus.com/inward/record.url?scp=76749152289&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=76749152289&partnerID=8YFLogxK
U2 - 10.1378/chest.09-0998
DO - 10.1378/chest.09-0998
M3 - Article
C2 - 19837825
AN - SCOPUS:76749152289
VL - 137
SP - 416
EP - 420
JO - Chest
JF - Chest
SN - 0012-3692
IS - 2
ER -