TY - JOUR
T1 - Thrombocytopenia in idiopathic inflammatory myopathies
T2 - A case series analysis
AU - Giannini, Margherita
AU - Grignaschi, Silvia
AU - Fornaro, Marco
AU - Caporali, Roberto
AU - Locatelli, Francesco
AU - Zanframundo, Giovanni
AU - Meyer, Alain
AU - Montecucco, Carlomaurizio
AU - Iannone, Florenzo
AU - Paolino, Sabrina
AU - Cavagna, Lorenzo
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Idiopathic inflammatory myopathies (IIMs) are a group of rare connective tissue diseases (CTDs) deeply affecting patients’prognosis. Extra-muscular involvement is not rare and skin, joints and lung are the most common targets. However, also dyserythropoiesis has been described, carrying relevant issues on patients’management and follow-up, as for example, lymphopenia has been associated with an increased risk of rapid progressive interstitial lung disease in anti-MDA5 positive dermatomyositis. Conversely to systemic lupus erythematosus, thrombocytopenia has only been rarely described in IIMs and very few authors focused on its potential prognostic implications. We describe five cases of thrombocytopenia in IIMs patients positive for myositis specific (MSA) or associated (MAA) autoantibodies. These reports extend the spectrum of haematological features associated to IIMs, focusing also on potential risk factors for thrombocytopenia occurrence.
AB - Idiopathic inflammatory myopathies (IIMs) are a group of rare connective tissue diseases (CTDs) deeply affecting patients’prognosis. Extra-muscular involvement is not rare and skin, joints and lung are the most common targets. However, also dyserythropoiesis has been described, carrying relevant issues on patients’management and follow-up, as for example, lymphopenia has been associated with an increased risk of rapid progressive interstitial lung disease in anti-MDA5 positive dermatomyositis. Conversely to systemic lupus erythematosus, thrombocytopenia has only been rarely described in IIMs and very few authors focused on its potential prognostic implications. We describe five cases of thrombocytopenia in IIMs patients positive for myositis specific (MSA) or associated (MAA) autoantibodies. These reports extend the spectrum of haematological features associated to IIMs, focusing also on potential risk factors for thrombocytopenia occurrence.
KW - Idiopathic inflammatory myopathies
KW - Myositis specific antibodies
KW - Myositis-associated antibodies
KW - Thrombocytopenia
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M3 - Article
C2 - 31820722
AN - SCOPUS:85092577892
VL - 38
SP - 891
EP - 895
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 5
ER -