Thrombocytopenia in idiopathic inflammatory myopathies: A case series analysis

Margherita Giannini, Silvia Grignaschi, Marco Fornaro, Roberto Caporali, Francesco Locatelli, Giovanni Zanframundo, Alain Meyer, Carlomaurizio Montecucco, Florenzo Iannone, Sabrina Paolino, Lorenzo Cavagna

Research output: Contribution to journalArticlepeer-review

Abstract

Idiopathic inflammatory myopathies (IIMs) are a group of rare connective tissue diseases (CTDs) deeply affecting patients’prognosis. Extra-muscular involvement is not rare and skin, joints and lung are the most common targets. However, also dyserythropoiesis has been described, carrying relevant issues on patients’management and follow-up, as for example, lymphopenia has been associated with an increased risk of rapid progressive interstitial lung disease in anti-MDA5 positive dermatomyositis. Conversely to systemic lupus erythematosus, thrombocytopenia has only been rarely described in IIMs and very few authors focused on its potential prognostic implications. We describe five cases of thrombocytopenia in IIMs patients positive for myositis specific (MSA) or associated (MAA) autoantibodies. These reports extend the spectrum of haematological features associated to IIMs, focusing also on potential risk factors for thrombocytopenia occurrence.

Original languageEnglish
Pages (from-to)891-895
Number of pages5
JournalClinical and Experimental Rheumatology
Volume38
Issue number5
Publication statusPublished - Sep 1 2020

Keywords

  • Idiopathic inflammatory myopathies
  • Myositis specific antibodies
  • Myositis-associated antibodies
  • Thrombocytopenia

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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