Thrombolytic therapy. From myocardial to cerebral infarction

L. Candelise, C. Roncaglioni, E. Aritzu, A. Ciccone, A. P. Maggioni

Research output: Contribution to journalArticlepeer-review


Thrombolysis is proposed for the acute treatment of cerebral infarction as it is able to recanalize occluded arteries and thus potentially restore normal perfusion of the cerebral parenchyma, but the results concerning the efficacy of this treatment are still inconclusive. However, it has been fully demonstrated that thrombolytic treatment, leads to a significant reduction in mortality, in patients with acute myocardial infarction. Data from all of the pilot studies using SK or tPA treatment in acute stroke are described in this review, which underlines the incidence of hemorrhagic transformation (hemorrhagic infart and parenchymal hematoma) and its possible correlation to clinical worsening. Pharmacological, experimental and clinical studies encourage the carrying out of large-scale clinical trials using thrombolytics in patients with acute cerebral infarction. Significant data relating to ongoing controlled clinical trials will be available in the near future; only afer the analysis of these results will it be possible to confirm the efficacy of thrombolytics in acute stroke.

Original languageEnglish
Pages (from-to)5-21
Number of pages17
JournalItalian Journal of Neurological Sciences
Issue number1
Publication statusPublished - 1996


  • acute cerebral stroke
  • cerebral recanalization
  • myocardial infarction
  • thrombolytic therapy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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