Thrombolytic versus fibrinogenolytic activity of rt-PA and streptokinase in patients with acute myocardial infarction

D. Prisco, F. Bonechi, L. Scarti, M. Tramontana, R. Abbate, G. F. Gensini

Research output: Contribution to journalArticle

Abstract

In this study the concentration of plasma breakdown products of cross-linked fibrin (XDP), serum fibrinogen-fibrin degradation products (FDP), and plasma fibrinogen were measured before and at the end of the administration of single-chain recombinant tissue-type plasminogen activator (rt-PA, 100 mg IV over three hours) or streptokinase (1.5 million units over one hour), respectively, in two groups, each composed of 22 patients with acute myocardial infarction. The XDP concentration was not statistically different between the two groups at the end of thrombolytic treatment, whereas FDP and fibrinogen concentrations were significantly different (FDP: streptokinase 396 ± 287 vs rt-PA 177 ± 222 μg/mL, p <0.01; fibrinogen: streptokinase 71 ± 43 vs rt-PA 181 ± 49 mg/dL, p <0.001). These results indicate that the two drugs have equipotent thrombolytic activity at this administration regimen but that rt-PA causes a markedly more selective lysis of fibrin in comparison with streptokinase.

Original languageEnglish
Pages (from-to)616-620
Number of pages5
JournalAngiology
Volume41
Issue number8
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Prisco, D., Bonechi, F., Scarti, L., Tramontana, M., Abbate, R., & Gensini, G. F. (1990). Thrombolytic versus fibrinogenolytic activity of rt-PA and streptokinase in patients with acute myocardial infarction. Angiology, 41(8), 616-620.