Thrombomodulin expression in endothelial cells after contact with bone cement

Elisabetta Cenni, Gabriela Ciapetti, Donatella Granchi, Lucia Savarino, Alessandra Corradini, Melania Vancini, Alessandro Di Leo

Research output: Contribution to journalArticle

Abstract

The expression of thrombomodulin after contact with CMW® 1 bone cement extracts was studied in human umbilical vein endothelial cells. Cement extracts after 1 h and 7-day curing induced no significant variations in thrombomodulin antigen levels and in mRNA expression. Significant increase of thrombomodulin was observed when endothelial cells were treated with all-trans retinoic acid (ATRA). ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW® 1 bone cement does not impair the expression of thrombomodulin in endothelial cells.

Original languageEnglish
Pages (from-to)2159-2165
Number of pages7
JournalBiomaterials
Volume23
Issue number10
DOIs
Publication statusPublished - 2002

Keywords

  • Bone cement
  • Endothelial cell
  • Thrombomodulin

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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