Thrombomodulin expression in endothelial cells after contact with bone cement

Elisabetta Cenni; Gabriela Ciapetti; Donatella Granchi; Lucia Savarino; Alessandra Corradini; Melania Vancini; Alessandro Di Leo

doi:10.1016/S0142-9612(01)00347-7

Thrombomodulin expression in endothelial cells after contact with bone cement

Elisabetta Cenni, Gabriela Ciapetti, Donatella Granchi, Lucia Savarino, Alessandra Corradini, Melania Vancini, Alessandro Di Leo

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

The expression of thrombomodulin after contact with CMW® 1 bone cement extracts was studied in human umbilical vein endothelial cells. Cement extracts after 1 h and 7-day curing induced no significant variations in thrombomodulin antigen levels and in mRNA expression. Significant increase of thrombomodulin was observed when endothelial cells were treated with all-trans retinoic acid (ATRA). ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW® 1 bone cement does not impair the expression of thrombomodulin in endothelial cells.

Original language	English
Pages (from-to)	2159-2165
Number of pages	7
Journal	Biomaterials
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/S0142-9612(01)00347-7
Publication status	Published - 2002

Keywords

Bone cement
Endothelial cell
Thrombomodulin

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/S0142-9612(01)00347-7

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title = "Thrombomodulin expression in endothelial cells after contact with bone cement",

abstract = "The expression of thrombomodulin after contact with CMW{\textregistered} 1 bone cement extracts was studied in human umbilical vein endothelial cells. Cement extracts after 1 h and 7-day curing induced no significant variations in thrombomodulin antigen levels and in mRNA expression. Significant increase of thrombomodulin was observed when endothelial cells were treated with all-trans retinoic acid (ATRA). ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW{\textregistered} 1 bone cement does not impair the expression of thrombomodulin in endothelial cells.",

keywords = "Bone cement, Endothelial cell, Thrombomodulin",

author = "Elisabetta Cenni and Gabriela Ciapetti and Donatella Granchi and Lucia Savarino and Alessandra Corradini and Melania Vancini and Leo, {Alessandro Di}",

year = "2002",

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T1 - Thrombomodulin expression in endothelial cells after contact with bone cement

AU - Cenni, Elisabetta

AU - Ciapetti, Gabriela

AU - Granchi, Donatella

AU - Savarino, Lucia

AU - Corradini, Alessandra

AU - Vancini, Melania

AU - Leo, Alessandro Di

PY - 2002

Y1 - 2002

N2 - The expression of thrombomodulin after contact with CMW® 1 bone cement extracts was studied in human umbilical vein endothelial cells. Cement extracts after 1 h and 7-day curing induced no significant variations in thrombomodulin antigen levels and in mRNA expression. Significant increase of thrombomodulin was observed when endothelial cells were treated with all-trans retinoic acid (ATRA). ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW® 1 bone cement does not impair the expression of thrombomodulin in endothelial cells.

AB - The expression of thrombomodulin after contact with CMW® 1 bone cement extracts was studied in human umbilical vein endothelial cells. Cement extracts after 1 h and 7-day curing induced no significant variations in thrombomodulin antigen levels and in mRNA expression. Significant increase of thrombomodulin was observed when endothelial cells were treated with all-trans retinoic acid (ATRA). ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW® 1 bone cement does not impair the expression of thrombomodulin in endothelial cells.

KW - Bone cement

KW - Endothelial cell

KW - Thrombomodulin

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DO - 10.1016/S0142-9612(01)00347-7

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AN - SCOPUS:0036124325

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JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

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ER -

Thrombomodulin expression in endothelial cells after contact with bone cement

Abstract

Keywords

ASJC Scopus subject areas

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