Abstract
The expression of thrombomodulin after contact with CMW® 1 bone cement extracts was studied in human umbilical vein endothelial cells. Cement extracts after 1 h and 7-day curing induced no significant variations in thrombomodulin antigen levels and in mRNA expression. Significant increase of thrombomodulin was observed when endothelial cells were treated with all-trans retinoic acid (ATRA). ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW® 1 bone cement does not impair the expression of thrombomodulin in endothelial cells.
| Original language | English |
|---|---|
| Pages (from-to) | 2159-2165 |
| Number of pages | 7 |
| Journal | Biomaterials |
| Volume | 23 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2002 |
Keywords
- Bone cement
- Endothelial cell
- Thrombomodulin
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
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Cite this
Cenni, E., Ciapetti, G., Granchi, D., Savarino, L., Corradini, A., Vancini, M., & Leo, A. D. (2002). Thrombomodulin expression in endothelial cells after contact with bone cement. Biomaterials, 23(10), 2159-2165. https://doi.org/10.1016/S0142-9612(01)00347-7