Abstract
The expression of thrombomodulin after contact with CMW® 1 bone cement extracts was studied in human umbilical vein endothelial cells. Cement extracts after 1 h and 7-day curing induced no significant variations in thrombomodulin antigen levels and in mRNA expression. Significant increase of thrombomodulin was observed when endothelial cells were treated with all-trans retinoic acid (ATRA). ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW® 1 bone cement does not impair the expression of thrombomodulin in endothelial cells.
| Original language | English |
|---|---|
| Pages (from-to) | 2159-2165 |
| Number of pages | 7 |
| Journal | Biomaterials |
| Volume | 23 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Bone cement
- Endothelial cell
- Thrombomodulin
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
Cite this
Thrombomodulin expression in endothelial cells after contact with bone cement. / Cenni, Elisabetta; Ciapetti, Gabriela; Granchi, Donatella; Savarino, Lucia; Corradini, Alessandra; Vancini, Melania; Leo, Alessandro Di.
In: Biomaterials, Vol. 23, No. 10, 2002, p. 2159-2165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thrombomodulin expression in endothelial cells after contact with bone cement
AU - Cenni, Elisabetta
AU - Ciapetti, Gabriela
AU - Granchi, Donatella
AU - Savarino, Lucia
AU - Corradini, Alessandra
AU - Vancini, Melania
AU - Leo, Alessandro Di
PY - 2002
Y1 - 2002
N2 - The expression of thrombomodulin after contact with CMW® 1 bone cement extracts was studied in human umbilical vein endothelial cells. Cement extracts after 1 h and 7-day curing induced no significant variations in thrombomodulin antigen levels and in mRNA expression. Significant increase of thrombomodulin was observed when endothelial cells were treated with all-trans retinoic acid (ATRA). ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW® 1 bone cement does not impair the expression of thrombomodulin in endothelial cells.
AB - The expression of thrombomodulin after contact with CMW® 1 bone cement extracts was studied in human umbilical vein endothelial cells. Cement extracts after 1 h and 7-day curing induced no significant variations in thrombomodulin antigen levels and in mRNA expression. Significant increase of thrombomodulin was observed when endothelial cells were treated with all-trans retinoic acid (ATRA). ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW® 1 bone cement does not impair the expression of thrombomodulin in endothelial cells.
KW - Bone cement
KW - Endothelial cell
KW - Thrombomodulin
UR - http://www.scopus.com/inward/record.url?scp=0036124325&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036124325&partnerID=8YFLogxK
U2 - 10.1016/S0142-9612(01)00347-7
DO - 10.1016/S0142-9612(01)00347-7
M3 - Article
C2 - 11962657
AN - SCOPUS:0036124325
VL - 23
SP - 2159
EP - 2165
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 10
ER -