Thrombophilia and fetal germinal matrix-intraventricular hemorrhage: Does it matter?

Research output: Contribution to journalArticle

Abstract

Germinal matrix-intraventricular hemorrhage (GMH-IVH) in the fetus is very rare and the role of thrombophilia in its pathogenesis is unclear. We report on the prenatal diagnosis by magnetic resonance imaging of GMH-IVH in a 24-week fetus. The newborn presented posthemorrhagic ventriculomegaly and was found to be heterozygous for two thrombophilic patterns, factor V Leiden and methylenetetrahydrofolate reductase mutation. The combination of this hypercoagulable state and prenatal GMH-IVH is discussed together with the opportunity of testing these infants for thrombophilia.

Original languageEnglish
Pages (from-to)574-576
Number of pages3
JournalUltrasound in Obstetrics and Gynecology
Volume26
Issue number5
DOIs
Publication statusPublished - Oct 2005

Fingerprint

hemorrhages
Thrombophilia
fetuses
Fetus
Hemorrhage
Methylenetetrahydrofolate Reductase (NADPH2)
pathogenesis
mutations
matrices
Prenatal Diagnosis
magnetic resonance
Magnetic Resonance Imaging
Newborn Infant
Mutation
factor V Leiden

Keywords

  • Factor V leiden
  • Fetal hemorrhage
  • GMH-IVH
  • Thrombophilia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Radiology Nuclear Medicine and imaging
  • Reproductive Medicine
  • Acoustics and Ultrasonics
  • Radiological and Ultrasound Technology

Cite this

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title = "Thrombophilia and fetal germinal matrix-intraventricular hemorrhage: Does it matter?",
abstract = "Germinal matrix-intraventricular hemorrhage (GMH-IVH) in the fetus is very rare and the role of thrombophilia in its pathogenesis is unclear. We report on the prenatal diagnosis by magnetic resonance imaging of GMH-IVH in a 24-week fetus. The newborn presented posthemorrhagic ventriculomegaly and was found to be heterozygous for two thrombophilic patterns, factor V Leiden and methylenetetrahydrofolate reductase mutation. The combination of this hypercoagulable state and prenatal GMH-IVH is discussed together with the opportunity of testing these infants for thrombophilia.",
keywords = "Factor V leiden, Fetal hemorrhage, GMH-IVH, Thrombophilia",
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T1 - Thrombophilia and fetal germinal matrix-intraventricular hemorrhage

T2 - Does it matter?

AU - Ramenghi, L. A.

AU - Fumagalli, M.

AU - Righini, A.

AU - Triulzi, F.

AU - Kustermann, A.

AU - Mosca, F.

PY - 2005/10

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AB - Germinal matrix-intraventricular hemorrhage (GMH-IVH) in the fetus is very rare and the role of thrombophilia in its pathogenesis is unclear. We report on the prenatal diagnosis by magnetic resonance imaging of GMH-IVH in a 24-week fetus. The newborn presented posthemorrhagic ventriculomegaly and was found to be heterozygous for two thrombophilic patterns, factor V Leiden and methylenetetrahydrofolate reductase mutation. The combination of this hypercoagulable state and prenatal GMH-IVH is discussed together with the opportunity of testing these infants for thrombophilia.

KW - Factor V leiden

KW - Fetal hemorrhage

KW - GMH-IVH

KW - Thrombophilia

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