Thrombophilic mutations in high-risk atrial fibrillation patients: High prevalence of prothrombin gene G20210A polymorphism and lack of correlation with thromboembolism

Daniela Poli; Emilia Antonucci; Emanuele Cecchi; Irene Betti; Lelia Valdrè; Cristina Mugnaini; Bruno Alterini; Alessandro Morettini; Carlo Nozzoli; Rosanna Abbate; Gian Franco Gensini; Domenico Prisco

Thrombophilic mutations in high-risk atrial fibrillation patients: High prevalence of prothrombin gene G20210A polymorphism and lack of correlation with thromboembolism

Daniela Poli, Emilia Antonucci, Emanuele Cecchi, Irene Betti, Lelia Valdrè, Cristina Mugnaini, Bruno Alterini, Alessandro Morettini, Carlo Nozzoli, Rosanna Abbate, Gian Franco Gensini, Domenico Prisco

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Atrial fibrillation (AF) is a common arrhythmia that results in a high risk of cerebral and peripheral embolism. Factor V Leiden and factor II G20210A variant are two leading conditions for venous thrombosis. The aim of our study was to find out whether these two common prothrombotic mutations play a role in the occurrence of embolic events in AF patients. We investigated 336 non-valvular AF patients and 336 healthy control subjects. Factor II G20210A variant was found in 24/336 patients (7.14%) and in 11/336 of control subjects (3.3%). At a multivariate analysis, factor II G20210A variant was independently associated to AF (OR 2.4 95% CI 1.1-5.2; p

Original language	English
Pages (from-to)	1158-1162
Number of pages	5
Journal	Thrombosis and Haemostasis
Volume	90
Issue number	6
Publication status	Published - Dec 2003

Keywords

Atrial fibrillation
Factor V Leiden
Prothrombin gene
Stroke

ASJC Scopus subject areas

Hematology

Cite this

Poli, D., Antonucci, E., Cecchi, E., Betti, I., Valdrè, L., Mugnaini, C., Alterini, B., Morettini, A., Nozzoli, C., Abbate, R., Gensini, G. F., & Prisco, D. (2003). Thrombophilic mutations in high-risk atrial fibrillation patients: High prevalence of prothrombin gene G20210A polymorphism and lack of correlation with thromboembolism. Thrombosis and Haemostasis, 90(6), 1158-1162.

Thrombophilic mutations in high-risk atrial fibrillation patients : High prevalence of prothrombin gene G20210A polymorphism and lack of correlation with thromboembolism. / Poli, Daniela; Antonucci, Emilia; Cecchi, Emanuele; Betti, Irene; Valdrè, Lelia; Mugnaini, Cristina; Alterini, Bruno; Morettini, Alessandro; Nozzoli, Carlo; Abbate, Rosanna; Gensini, Gian Franco; Prisco, Domenico.

In: Thrombosis and Haemostasis, Vol. 90, No. 6, 12.2003, p. 1158-1162.

Research output: Contribution to journal › Article › peer-review

Poli, D, Antonucci, E, Cecchi, E, Betti, I, Valdrè, L, Mugnaini, C, Alterini, B, Morettini, A, Nozzoli, C, Abbate, R, Gensini, GF & Prisco, D 2003, 'Thrombophilic mutations in high-risk atrial fibrillation patients: High prevalence of prothrombin gene G20210A polymorphism and lack of correlation with thromboembolism', Thrombosis and Haemostasis, vol. 90, no. 6, pp. 1158-1162.

Poli, Daniela ; Antonucci, Emilia ; Cecchi, Emanuele ; Betti, Irene ; Valdrè, Lelia ; Mugnaini, Cristina ; Alterini, Bruno ; Morettini, Alessandro ; Nozzoli, Carlo ; Abbate, Rosanna ; Gensini, Gian Franco ; Prisco, Domenico. / Thrombophilic mutations in high-risk atrial fibrillation patients : High prevalence of prothrombin gene G20210A polymorphism and lack of correlation with thromboembolism. In: Thrombosis and Haemostasis. 2003 ; Vol. 90, No. 6. pp. 1158-1162.

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abstract = "Atrial fibrillation (AF) is a common arrhythmia that results in a high risk of cerebral and peripheral embolism. Factor V Leiden and factor II G20210A variant are two leading conditions for venous thrombosis. The aim of our study was to find out whether these two common prothrombotic mutations play a role in the occurrence of embolic events in AF patients. We investigated 336 non-valvular AF patients and 336 healthy control subjects. Factor II G20210A variant was found in 24/336 patients (7.14%) and in 11/336 of control subjects (3.3%). At a multivariate analysis, factor II G20210A variant was independently associated to AF (OR 2.4 95% CI 1.1-5.2; p",

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AU - Cecchi, Emanuele

AU - Betti, Irene

AU - Valdrè, Lelia

AU - Mugnaini, Cristina

AU - Alterini, Bruno

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AB - Atrial fibrillation (AF) is a common arrhythmia that results in a high risk of cerebral and peripheral embolism. Factor V Leiden and factor II G20210A variant are two leading conditions for venous thrombosis. The aim of our study was to find out whether these two common prothrombotic mutations play a role in the occurrence of embolic events in AF patients. We investigated 336 non-valvular AF patients and 336 healthy control subjects. Factor II G20210A variant was found in 24/336 patients (7.14%) and in 11/336 of control subjects (3.3%). At a multivariate analysis, factor II G20210A variant was independently associated to AF (OR 2.4 95% CI 1.1-5.2; p

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Thrombophilic mutations in high-risk atrial fibrillation patients: High prevalence of prothrombin gene G20210A polymorphism and lack of correlation with thromboembolism

Abstract

Keywords

ASJC Scopus subject areas

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