Abstract
Atrial fibrillation (AF) is a common arrhythmia that results in a high risk of cerebral and peripheral embolism. Factor V Leiden and factor II G20210A variant are two leading conditions for venous thrombosis. The aim of our study was to find out whether these two common prothrombotic mutations play a role in the occurrence of embolic events in AF patients. We investigated 336 non-valvular AF patients and 336 healthy control subjects. Factor II G20210A variant was found in 24/336 patients (7.14%) and in 11/336 of control subjects (3.3%). At a multivariate analysis, factor II G20210A variant was independently associated to AF (OR 2.4 95% CI 1.1-5.2; p
Original language | English |
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Pages (from-to) | 1158-1162 |
Number of pages | 5 |
Journal | Thrombosis and Haemostasis |
Volume | 90 |
Issue number | 6 |
Publication status | Published - Dec 2003 |
Keywords
- Atrial fibrillation
- Factor V Leiden
- Prothrombin gene
- Stroke
ASJC Scopus subject areas
- Hematology