Thrombophilic mutations in high-risk atrial fibrillation patients: High prevalence of prothrombin gene G20210A polymorphism and lack of correlation with thromboembolism

Daniela Poli, Emilia Antonucci, Emanuele Cecchi, Irene Betti, Lelia Valdrè, Cristina Mugnaini, Bruno Alterini, Alessandro Morettini, Carlo Nozzoli, Rosanna Abbate, Gian Franco Gensini, Domenico Prisco

Research output: Contribution to journalArticlepeer-review

Abstract

Atrial fibrillation (AF) is a common arrhythmia that results in a high risk of cerebral and peripheral embolism. Factor V Leiden and factor II G20210A variant are two leading conditions for venous thrombosis. The aim of our study was to find out whether these two common prothrombotic mutations play a role in the occurrence of embolic events in AF patients. We investigated 336 non-valvular AF patients and 336 healthy control subjects. Factor II G20210A variant was found in 24/336 patients (7.14%) and in 11/336 of control subjects (3.3%). At a multivariate analysis, factor II G20210A variant was independently associated to AF (OR 2.4 95% CI 1.1-5.2; p

Original languageEnglish
Pages (from-to)1158-1162
Number of pages5
JournalThrombosis and Haemostasis
Volume90
Issue number6
Publication statusPublished - Dec 2003

Keywords

  • Atrial fibrillation
  • Factor V Leiden
  • Prothrombin gene
  • Stroke

ASJC Scopus subject areas

  • Hematology

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