Thrombophilic risk factors in patients with severe carotid atherosclerosis

R. Marcucci, F. Sofi, S. Fedi, B. Lari, I. Sestini, A. P. Cellai, R. Pulli, G. Pratesi, C. Pratesi, G. F. Gensini, R. Abbate

Research output: Contribution to journalArticle

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Abstract

Carotid stenosis and atrial fibrillation are the strongest risk factors for ischemic stroke. Ongoing prevention efforts include the identification of novel factors that increase the risk for carotid atherosclerosis. The aim of this study was to determine the thrombophilic risk profile of patients with severe carotid stenosis by evaluating a number of genetic and metabolic risk factors [factor (F)II G20210A, factor V Leiden, MTHFR C677T polymorphisms, anticardiolipin antibodies (aCL), lipoprotein(a) (Lp(a)), and homocysteine (Hcy)]. The study population consisted of 615 patients [(410 M/205 F; median age 73 (26-94) years] with severe ( > 70%) carotid stenosis, and 615 apparently healthy subjects [(410 M/205 F; age 73 (31-92) years]. On multivariate analysis, independent risk factors were elevated Hcy [odds ratio (OR) 7.6, 95% confidence interval (CI) 4.8, 11.8] and Lp(a) levels (OR 2.9, 95% CI 2.1, 3.9), the presence of aCL (OR 5.7, 95% CI 3.1, 10.4) and heterozygosity for FII G20210A polymorphism (OR 2.8, 95% CI 1.3, 5.9). In the subgroup of women, independent risk factors for severe carotid atherosclerosis were: high levels of Hcy and Lp(a) and the presence of aCL, whereas hyperhomocysteinemia, elevated Lp(a) levels, aCL, FII G20210A and MTHFR 677TT polymorphisms remained independent risk factors in the subgroup of men. The results of the present study demonstrate that the prevalence of the thrombophilic risk factors is increased in patients with severe carotid atherosclerosis.

Original languageEnglish
Pages (from-to)502-507
Number of pages6
JournalJournal of Thrombosis and Haemostasis
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Carotid Artery Diseases
Anticardiolipin Antibodies
Lipoprotein(a)
Carotid Stenosis
Homocysteine
Odds Ratio
Confidence Intervals
Hyperhomocysteinemia
Atrial Fibrillation
Healthy Volunteers
Multivariate Analysis
Cross-Sectional Studies
Stroke
Population

Keywords

  • Carotid artery
  • Gene polymorphisms
  • Hemostasis
  • Homocysteine
  • Lipoprotein(a)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thrombophilic risk factors in patients with severe carotid atherosclerosis. / Marcucci, R.; Sofi, F.; Fedi, S.; Lari, B.; Sestini, I.; Cellai, A. P.; Pulli, R.; Pratesi, G.; Pratesi, C.; Gensini, G. F.; Abbate, R.

In: Journal of Thrombosis and Haemostasis, Vol. 3, No. 3, 03.2005, p. 502-507.

Research output: Contribution to journalArticle

Marcucci, R, Sofi, F, Fedi, S, Lari, B, Sestini, I, Cellai, AP, Pulli, R, Pratesi, G, Pratesi, C, Gensini, GF & Abbate, R 2005, 'Thrombophilic risk factors in patients with severe carotid atherosclerosis', Journal of Thrombosis and Haemostasis, vol. 3, no. 3, pp. 502-507. https://doi.org/10.1111/j.1538-7836.2005.01173.x
Marcucci, R. ; Sofi, F. ; Fedi, S. ; Lari, B. ; Sestini, I. ; Cellai, A. P. ; Pulli, R. ; Pratesi, G. ; Pratesi, C. ; Gensini, G. F. ; Abbate, R. / Thrombophilic risk factors in patients with severe carotid atherosclerosis. In: Journal of Thrombosis and Haemostasis. 2005 ; Vol. 3, No. 3. pp. 502-507.
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AU - Sofi, F.

AU - Fedi, S.

AU - Lari, B.

AU - Sestini, I.

AU - Cellai, A. P.

AU - Pulli, R.

AU - Pratesi, G.

AU - Pratesi, C.

AU - Gensini, G. F.

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