Abstract
Introduction: Despite extensive clinical and laboratory investigations, the etiology of ischemic stroke remains unknown in approximately one third of patients. Materials and Methods: Thirty-four consecutive patients less than 40 years old (Males 13, Females 21, mean age 26.6 years, range 2-39) with documented ischemic stroke underwent, one year after the acute event, laboratory evaluation of antithrombin, protein C, free and total protein S, activated protein C resistance, fibrinogen, factor VII:C, homocysteine levels and antiphospholipid antibodies (APA). Moreover, prevalence of F5 R506Q, F2 G2021A and homozygosis for thermolabile variant C677T of the methylenetetrahydrofolate reductase (MTHFR) were also evaluated and compared to the results obtained in 120 normal controls. Results: Antithrombin and protein C levels resulted normal in all cases. One patient (2.9%) showed free protein S deficiency and 3 patients (8.8%) had activated protein C resistance. Homocysteine levels above 15 μmol/L were found in one patient (2.9%). APA were found in 21 patients (61.7%) and in only 2 out of 120 (1.66%) controls (OR = 95.31; 95% C.I.: 18.22-667.81). The multivariate analysis selected that the presence of APA was significantly associated with an increased risk of stroke (OR = 156.60; 95% C.I.: 25.99-943.47) in this cohort of patients. The combination between APA and cardiovascular risk factors determined a risk of 29-fold (OR = 29.31; 95% CI: 3.28-261.69). Discussion: Our data suggest that the presence of APA is associated with an increased risk of idiopathic ischemic stroke in young patients. Furthermore, also the combination of APA and cardiovascular risk factors is significantly associated with development of idiopathic ischemic stroke.
| Original language | English |
|---|---|
| Pages (from-to) | 85-90 |
| Number of pages | 6 |
| Journal | Thrombosis Research |
| Volume | 127 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2011 |
Fingerprint
Keywords
- Antiphospholipid antibodies
- Ischemic stroke
- Thrombophilic screening
- Young patients
ASJC Scopus subject areas
- Hematology
Cite this
Thrombophilic screening in young patients (<40 years) with idiopathic ischemic stroke : A controlled study. / Dragoni, Francesco; Chiarotti, Flavia; Rosano, Giuseppe; Simioni, Paolo; Tormene, Daniela; Mazzucconi, Maria Gabriella; Cafolla, Arturo; Avvisati, Giuseppe.
In: Thrombosis Research, Vol. 127, No. 2, 02.2011, p. 85-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thrombophilic screening in young patients (<40 years) with idiopathic ischemic stroke
T2 - A controlled study
AU - Dragoni, Francesco
AU - Chiarotti, Flavia
AU - Rosano, Giuseppe
AU - Simioni, Paolo
AU - Tormene, Daniela
AU - Mazzucconi, Maria Gabriella
AU - Cafolla, Arturo
AU - Avvisati, Giuseppe
PY - 2011/2
Y1 - 2011/2
N2 - Introduction: Despite extensive clinical and laboratory investigations, the etiology of ischemic stroke remains unknown in approximately one third of patients. Materials and Methods: Thirty-four consecutive patients less than 40 years old (Males 13, Females 21, mean age 26.6 years, range 2-39) with documented ischemic stroke underwent, one year after the acute event, laboratory evaluation of antithrombin, protein C, free and total protein S, activated protein C resistance, fibrinogen, factor VII:C, homocysteine levels and antiphospholipid antibodies (APA). Moreover, prevalence of F5 R506Q, F2 G2021A and homozygosis for thermolabile variant C677T of the methylenetetrahydrofolate reductase (MTHFR) were also evaluated and compared to the results obtained in 120 normal controls. Results: Antithrombin and protein C levels resulted normal in all cases. One patient (2.9%) showed free protein S deficiency and 3 patients (8.8%) had activated protein C resistance. Homocysteine levels above 15 μmol/L were found in one patient (2.9%). APA were found in 21 patients (61.7%) and in only 2 out of 120 (1.66%) controls (OR = 95.31; 95% C.I.: 18.22-667.81). The multivariate analysis selected that the presence of APA was significantly associated with an increased risk of stroke (OR = 156.60; 95% C.I.: 25.99-943.47) in this cohort of patients. The combination between APA and cardiovascular risk factors determined a risk of 29-fold (OR = 29.31; 95% CI: 3.28-261.69). Discussion: Our data suggest that the presence of APA is associated with an increased risk of idiopathic ischemic stroke in young patients. Furthermore, also the combination of APA and cardiovascular risk factors is significantly associated with development of idiopathic ischemic stroke.
AB - Introduction: Despite extensive clinical and laboratory investigations, the etiology of ischemic stroke remains unknown in approximately one third of patients. Materials and Methods: Thirty-four consecutive patients less than 40 years old (Males 13, Females 21, mean age 26.6 years, range 2-39) with documented ischemic stroke underwent, one year after the acute event, laboratory evaluation of antithrombin, protein C, free and total protein S, activated protein C resistance, fibrinogen, factor VII:C, homocysteine levels and antiphospholipid antibodies (APA). Moreover, prevalence of F5 R506Q, F2 G2021A and homozygosis for thermolabile variant C677T of the methylenetetrahydrofolate reductase (MTHFR) were also evaluated and compared to the results obtained in 120 normal controls. Results: Antithrombin and protein C levels resulted normal in all cases. One patient (2.9%) showed free protein S deficiency and 3 patients (8.8%) had activated protein C resistance. Homocysteine levels above 15 μmol/L were found in one patient (2.9%). APA were found in 21 patients (61.7%) and in only 2 out of 120 (1.66%) controls (OR = 95.31; 95% C.I.: 18.22-667.81). The multivariate analysis selected that the presence of APA was significantly associated with an increased risk of stroke (OR = 156.60; 95% C.I.: 25.99-943.47) in this cohort of patients. The combination between APA and cardiovascular risk factors determined a risk of 29-fold (OR = 29.31; 95% CI: 3.28-261.69). Discussion: Our data suggest that the presence of APA is associated with an increased risk of idiopathic ischemic stroke in young patients. Furthermore, also the combination of APA and cardiovascular risk factors is significantly associated with development of idiopathic ischemic stroke.
KW - Antiphospholipid antibodies
KW - Ischemic stroke
KW - Thrombophilic screening
KW - Young patients
UR - http://www.scopus.com/inward/record.url?scp=79151478201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79151478201&partnerID=8YFLogxK
U2 - 10.1016/j.thromres.2010.11.013
DO - 10.1016/j.thromres.2010.11.013
M3 - Article
C2 - 21172722
AN - SCOPUS:79151478201
VL - 127
SP - 85
EP - 90
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
IS - 2
ER -