Thrombosis and Acute coronary syndrome

Rosanna Abbate, Gabriele Cioni, Ilaria Ricci, Marco Miranda, Anna Maria Gori

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Acute coronary syndromes (ACS) represent the main clinical manifestation of atherosclerotic progression in the coronary district. Thrombosis plays a critical role in the patho-anatomical of ACS, as disruption of an atherosclerotic plaque exposes flowing blood to subendothelial collagen, tissue factor, and other procoagulant molecules that trigger activation of platelets and formation of fibrin within the vessel lumen. Endothelial damage/dysfunction, inflammation and coagulation are closely related to the pathophysiology of ACS and may be inter-related. Platelets play key roles in both the formation of the atheromatous plaque and clinical presentation of acute atherothrombotic events following plaque rupture. In the pathogenesis of the ACS, blood clotting activation has a crucial role and thrombin generation and TF may represent useful markers for the identification of patients at high risk of vascular events. Lipoprotein-associated phospholipase A2 (Lp-PLA2) represents the crossroads between lipid metabolism and inflammatory response.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalThrombosis Research
Volume129
Issue number3
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Acute Coronary Syndrome
Thrombosis
Atherosclerotic Plaques
1-Alkyl-2-acetylglycerophosphocholine Esterase
Platelet Activation
Thromboplastin
Blood Coagulation
Fibrin
Lipid Metabolism
Thrombin
Blood Vessels
Rupture
Collagen
Blood Platelets
Inflammation

Keywords

  • Acute coronary syndrome
  • Hemostasis
  • Inflammation
  • Thrombosis

ASJC Scopus subject areas

  • Hematology

Cite this

Abbate, R., Cioni, G., Ricci, I., Miranda, M., & Gori, A. M. (2012). Thrombosis and Acute coronary syndrome. Thrombosis Research, 129(3), 235-240. https://doi.org/10.1016/j.thromres.2011.12.026

Thrombosis and Acute coronary syndrome. / Abbate, Rosanna; Cioni, Gabriele; Ricci, Ilaria; Miranda, Marco; Gori, Anna Maria.

In: Thrombosis Research, Vol. 129, No. 3, 03.2012, p. 235-240.

Research output: Contribution to journalArticle

Abbate, R, Cioni, G, Ricci, I, Miranda, M & Gori, AM 2012, 'Thrombosis and Acute coronary syndrome', Thrombosis Research, vol. 129, no. 3, pp. 235-240. https://doi.org/10.1016/j.thromres.2011.12.026
Abbate R, Cioni G, Ricci I, Miranda M, Gori AM. Thrombosis and Acute coronary syndrome. Thrombosis Research. 2012 Mar;129(3):235-240. https://doi.org/10.1016/j.thromres.2011.12.026
Abbate, Rosanna ; Cioni, Gabriele ; Ricci, Ilaria ; Miranda, Marco ; Gori, Anna Maria. / Thrombosis and Acute coronary syndrome. In: Thrombosis Research. 2012 ; Vol. 129, No. 3. pp. 235-240.
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