Thrombosis and survival in essential thrombocythemia: A regional study of 1,144 patients

Marco Montanaro, Roberto Latagliata, Michele Cedrone, Antonio Spadea, Angela Rago, Jonny Di Giandomenico, Francesca Spirito, Raffaele Porrini, Marianna De Muro, Sabrina Crescenzi Leonetti, Nicoletta Villivà, Cinzia De Gregoris, Massimo Breccia, Enrico Montefusco, Cristina Santoro, Giuseppe Cimino, Ignazio Majolino, Maria Gabriella Mazzucconi, Giuliana Alimena, Alesssandro Andriani

Research output: Contribution to journalArticlepeer-review

Abstract

To identify prognostic factors affecting thrombosis-free survival (TFS) and overall survival (OS), we report the experience of a Regional cooperative group in a real-life cohort of 1,144 patients with essential thrombocythemia (ET) diagnosed from January 1979 to December 2010. There were 107 thrombotic events (9.4%) during follow-up [60 (5.3%) arterial and 47 (4.1%) venous thromboses]. At univariate analysis, risk factors for a shorter TFS were: age >60 years (P60 years (P15 × 109/l (P=0.0370) were independent risk factors. Previous thrombotic events in ET patients are crucial for TFS but their importance seems related not to the occurrence per se but mainly to the interval between the event and the diagnosis.

Original languageEnglish
Pages (from-to)542-546
Number of pages5
JournalAmerican Journal of Hematology
Volume89
Issue number5
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Hematology

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