TY - JOUR
T1 - Thrombosis and survival in essential thrombocythemia
T2 - A regional study of 1,144 patients
AU - Montanaro, Marco
AU - Latagliata, Roberto
AU - Cedrone, Michele
AU - Spadea, Antonio
AU - Rago, Angela
AU - Di Giandomenico, Jonny
AU - Spirito, Francesca
AU - Porrini, Raffaele
AU - De Muro, Marianna
AU - Leonetti, Sabrina Crescenzi
AU - Villivà, Nicoletta
AU - De Gregoris, Cinzia
AU - Breccia, Massimo
AU - Montefusco, Enrico
AU - Santoro, Cristina
AU - Cimino, Giuseppe
AU - Majolino, Ignazio
AU - Mazzucconi, Maria Gabriella
AU - Alimena, Giuliana
AU - Andriani, Alesssandro
PY - 2014
Y1 - 2014
N2 - To identify prognostic factors affecting thrombosis-free survival (TFS) and overall survival (OS), we report the experience of a Regional cooperative group in a real-life cohort of 1,144 patients with essential thrombocythemia (ET) diagnosed from January 1979 to December 2010. There were 107 thrombotic events (9.4%) during follow-up [60 (5.3%) arterial and 47 (4.1%) venous thromboses]. At univariate analysis, risk factors for a shorter TFS were: age >60 years (P60 years (P15 × 109/l (P=0.0370) were independent risk factors. Previous thrombotic events in ET patients are crucial for TFS but their importance seems related not to the occurrence per se but mainly to the interval between the event and the diagnosis.
AB - To identify prognostic factors affecting thrombosis-free survival (TFS) and overall survival (OS), we report the experience of a Regional cooperative group in a real-life cohort of 1,144 patients with essential thrombocythemia (ET) diagnosed from January 1979 to December 2010. There were 107 thrombotic events (9.4%) during follow-up [60 (5.3%) arterial and 47 (4.1%) venous thromboses]. At univariate analysis, risk factors for a shorter TFS were: age >60 years (P60 years (P15 × 109/l (P=0.0370) were independent risk factors. Previous thrombotic events in ET patients are crucial for TFS but their importance seems related not to the occurrence per se but mainly to the interval between the event and the diagnosis.
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U2 - 10.1002/ajh.23685
DO - 10.1002/ajh.23685
M3 - Article
C2 - 24481665
AN - SCOPUS:84898415131
VL - 89
SP - 542
EP - 546
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 5
ER -