Thrombosis and survival in essential thrombocythemia: A regional study of 1,144 patients

Marco Montanaro; Roberto Latagliata; Michele Cedrone; Antonio Spadea; Angela Rago; Jonny Di Giandomenico; Francesca Spirito; Raffaele Porrini; Marianna De Muro; Sabrina Crescenzi Leonetti; Nicoletta Villivà; Cinzia De Gregoris; Massimo Breccia; Enrico Montefusco; Cristina Santoro; Giuseppe Cimino; Ignazio Majolino; Maria Gabriella Mazzucconi; Giuliana Alimena; Alesssandro Andriani

doi:10.1002/ajh.23685

Thrombosis and survival in essential thrombocythemia: A regional study of 1,144 patients

Marco Montanaro, Roberto Latagliata, Michele Cedrone, Antonio Spadea, Angela Rago, Jonny Di Giandomenico, Francesca Spirito, Raffaele Porrini, Marianna De Muro, Sabrina Crescenzi Leonetti, Nicoletta Villivà, Cinzia De Gregoris, Massimo Breccia, Enrico Montefusco, Cristina Santoro, Giuseppe Cimino, Ignazio Majolino, Maria Gabriella Mazzucconi, Giuliana Alimena, Alesssandro Andriani

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

To identify prognostic factors affecting thrombosis-free survival (TFS) and overall survival (OS), we report the experience of a Regional cooperative group in a real-life cohort of 1,144 patients with essential thrombocythemia (ET) diagnosed from January 1979 to December 2010. There were 107 thrombotic events (9.4%) during follow-up [60 (5.3%) arterial and 47 (4.1%) venous thromboses]. At univariate analysis, risk factors for a shorter TFS were: age >60 years (P60 years (P15 × 10⁹/l (P=0.0370) were independent risk factors. Previous thrombotic events in ET patients are crucial for TFS but their importance seems related not to the occurrence per se but mainly to the interval between the event and the diagnosis.

Original language	English
Pages (from-to)	542-546
Number of pages	5
Journal	American Journal of Hematology
Volume	89
Issue number	5
DOIs	https://doi.org/10.1002/ajh.23685
Publication status	Published - 2014

ASJC Scopus subject areas

Hematology

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Montanaro, M., Latagliata, R., Cedrone, M., Spadea, A., Rago, A., Di Giandomenico, J., Spirito, F., Porrini, R., De Muro, M., Leonetti, S. C., Villivà, N., De Gregoris, C., Breccia, M., Montefusco, E., Santoro, C., Cimino, G., Majolino, I., Mazzucconi, M. G., Alimena, G., & Andriani, A. (2014). Thrombosis and survival in essential thrombocythemia: A regional study of 1,144 patients. American Journal of Hematology, 89(5), 542-546. https://doi.org/10.1002/ajh.23685

Thrombosis and survival in essential thrombocythemia : A regional study of 1,144 patients. / Montanaro, Marco; Latagliata, Roberto; Cedrone, Michele; Spadea, Antonio; Rago, Angela; Di Giandomenico, Jonny; Spirito, Francesca; Porrini, Raffaele; De Muro, Marianna; Leonetti, Sabrina Crescenzi; Villivà, Nicoletta; De Gregoris, Cinzia; Breccia, Massimo; Montefusco, Enrico; Santoro, Cristina; Cimino, Giuseppe; Majolino, Ignazio; Mazzucconi, Maria Gabriella; Alimena, Giuliana; Andriani, Alesssandro.

In: American Journal of Hematology, Vol. 89, No. 5, 2014, p. 542-546.

Research output: Contribution to journal › Article › peer-review

Montanaro, M, Latagliata, R, Cedrone, M, Spadea, A, Rago, A, Di Giandomenico, J, Spirito, F, Porrini, R, De Muro, M, Leonetti, SC, Villivà, N, De Gregoris, C, Breccia, M, Montefusco, E, Santoro, C, Cimino, G, Majolino, I, Mazzucconi, MG, Alimena, G & Andriani, A 2014, 'Thrombosis and survival in essential thrombocythemia: A regional study of 1,144 patients', American Journal of Hematology, vol. 89, no. 5, pp. 542-546. https://doi.org/10.1002/ajh.23685

Montanaro, Marco ; Latagliata, Roberto ; Cedrone, Michele ; Spadea, Antonio ; Rago, Angela ; Di Giandomenico, Jonny ; Spirito, Francesca ; Porrini, Raffaele ; De Muro, Marianna ; Leonetti, Sabrina Crescenzi ; Villivà, Nicoletta ; De Gregoris, Cinzia ; Breccia, Massimo ; Montefusco, Enrico ; Santoro, Cristina ; Cimino, Giuseppe ; Majolino, Ignazio ; Mazzucconi, Maria Gabriella ; Alimena, Giuliana ; Andriani, Alesssandro. / Thrombosis and survival in essential thrombocythemia : A regional study of 1,144 patients. In: American Journal of Hematology. 2014 ; Vol. 89, No. 5. pp. 542-546.

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abstract = "To identify prognostic factors affecting thrombosis-free survival (TFS) and overall survival (OS), we report the experience of a Regional cooperative group in a real-life cohort of 1,144 patients with essential thrombocythemia (ET) diagnosed from January 1979 to December 2010. There were 107 thrombotic events (9.4%) during follow-up [60 (5.3%) arterial and 47 (4.1%) venous thromboses]. At univariate analysis, risk factors for a shorter TFS were: age >60 years (P60 years (P15 × 109/l (P=0.0370) were independent risk factors. Previous thrombotic events in ET patients are crucial for TFS but their importance seems related not to the occurrence per se but mainly to the interval between the event and the diagnosis.",

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AU - Rago, Angela

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AU - Villivà, Nicoletta

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AU - Breccia, Massimo

AU - Montefusco, Enrico

AU - Santoro, Cristina

AU - Cimino, Giuseppe

AU - Majolino, Ignazio

AU - Mazzucconi, Maria Gabriella

AU - Alimena, Giuliana

AU - Andriani, Alesssandro

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Thrombosis and survival in essential thrombocythemia: A regional study of 1,144 patients

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