In order to evaluate the effects of rheologic and coagulative factors (haematocrit, plasma fibrinogen, platelet number and activity, plasma and blood viscosity) on vascular graft inner thrombus deposition, 30 tubular grafts, either of glutaraldehyde tanned collagen or polytetrafluorethylene, were sutured in the inferior vena cava of pigs. The grafts were removed one hour after implantation and the thrombus-lined surface area was calculated. The only factor significantly associated with the extent of the inner thrombus was platelet activity. Platelet consumption was also higher in animals with thrombus-lined grafts with respect to those with thrombus-free grafts. These findings emphasize the major role of platelets in the induction of thrombus deposition on vascular grafts.
|Translated title of the contribution||Thrombosis in biological and synthetic vascular grafts, evaluation of rheologic and coagulative factors|
|Number of pages||5|
|Publication status||Published - 1989|
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