Abstract
Although venous thrombosis has been traditionally associated with stasis and hypercoagulability, arterial thrombosis is mainly associated with heightened platelet reactivity and damage to the vessel wall. Accordingly, classic risk factors for venous and arterial thrombosis are usually considered distinct. Those for the former include cancer, surgery, pregnancy, and estrogens use, whereas risk factors of arterial thrombosis include smoking, hypertension, diabetes, the metabolic syndrome, and hyperlipidemia. However, a number of studies have recently challenged this dichotomy, and it is now recognized that venous and arterial thromboses share several risk factors, suggesting a closer link between the two clinical conditions. Typical examples of shared risk factors are age and the metabolic syndrome. This review addresses the mechanism whereby established risk factors increase the risk of venous or arterial thrombosis, or both.
| Original language | English |
|---|---|
| Journal | Critical Care Medicine |
| Volume | 38 |
| Issue number | SUPPL. 2 |
| DOIs | |
| Publication status | Published - Feb 2010 |
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Keywords
- Arterial thrombosis
- Coagulation
- Pathogenesis
- Risk factors
- Venous thrombosis
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
Thrombotic risk factors : Basic pathophysiology. / Martinelli, Ida; Bucciarelli, Paolo; Mannucci, Pier Mannuccio.
In: Critical Care Medicine, Vol. 38, No. SUPPL. 2, 02.2010.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thrombotic risk factors
T2 - Basic pathophysiology
AU - Martinelli, Ida
AU - Bucciarelli, Paolo
AU - Mannucci, Pier Mannuccio
PY - 2010/2
Y1 - 2010/2
N2 - Although venous thrombosis has been traditionally associated with stasis and hypercoagulability, arterial thrombosis is mainly associated with heightened platelet reactivity and damage to the vessel wall. Accordingly, classic risk factors for venous and arterial thrombosis are usually considered distinct. Those for the former include cancer, surgery, pregnancy, and estrogens use, whereas risk factors of arterial thrombosis include smoking, hypertension, diabetes, the metabolic syndrome, and hyperlipidemia. However, a number of studies have recently challenged this dichotomy, and it is now recognized that venous and arterial thromboses share several risk factors, suggesting a closer link between the two clinical conditions. Typical examples of shared risk factors are age and the metabolic syndrome. This review addresses the mechanism whereby established risk factors increase the risk of venous or arterial thrombosis, or both.
AB - Although venous thrombosis has been traditionally associated with stasis and hypercoagulability, arterial thrombosis is mainly associated with heightened platelet reactivity and damage to the vessel wall. Accordingly, classic risk factors for venous and arterial thrombosis are usually considered distinct. Those for the former include cancer, surgery, pregnancy, and estrogens use, whereas risk factors of arterial thrombosis include smoking, hypertension, diabetes, the metabolic syndrome, and hyperlipidemia. However, a number of studies have recently challenged this dichotomy, and it is now recognized that venous and arterial thromboses share several risk factors, suggesting a closer link between the two clinical conditions. Typical examples of shared risk factors are age and the metabolic syndrome. This review addresses the mechanism whereby established risk factors increase the risk of venous or arterial thrombosis, or both.
KW - Arterial thrombosis
KW - Coagulation
KW - Pathogenesis
KW - Risk factors
KW - Venous thrombosis
UR - http://www.scopus.com/inward/record.url?scp=74949100229&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74949100229&partnerID=8YFLogxK
U2 - 10.1097/CCM.0b013e3181c9cbd9
DO - 10.1097/CCM.0b013e3181c9cbd9
M3 - Article
VL - 38
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - SUPPL. 2
ER -