Thrombotic risk factors

Basic pathophysiology

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Although venous thrombosis has been traditionally associated with stasis and hypercoagulability, arterial thrombosis is mainly associated with heightened platelet reactivity and damage to the vessel wall. Accordingly, classic risk factors for venous and arterial thrombosis are usually considered distinct. Those for the former include cancer, surgery, pregnancy, and estrogens use, whereas risk factors of arterial thrombosis include smoking, hypertension, diabetes, the metabolic syndrome, and hyperlipidemia. However, a number of studies have recently challenged this dichotomy, and it is now recognized that venous and arterial thromboses share several risk factors, suggesting a closer link between the two clinical conditions. Typical examples of shared risk factors are age and the metabolic syndrome. This review addresses the mechanism whereby established risk factors increase the risk of venous or arterial thrombosis, or both.

Original languageEnglish
JournalCritical Care Medicine
Volume38
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Feb 2010

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Venous Thrombosis
Thrombosis
Thrombophilia
Hyperlipidemias
Estrogens
Blood Platelets
Smoking
Hypertension
Pregnancy
Neoplasms

Keywords

  • Arterial thrombosis
  • Coagulation
  • Pathogenesis
  • Risk factors
  • Venous thrombosis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Thrombotic risk factors : Basic pathophysiology. / Martinelli, Ida; Bucciarelli, Paolo; Mannucci, Pier Mannuccio.

In: Critical Care Medicine, Vol. 38, No. SUPPL. 2, 02.2010.

Research output: Contribution to journalArticle

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