Thrombotic thrombocitopenic purpura(TTP): A new therapeutic possibility

A. Notario, A. Spaghi, M. Celano, M. L. Rolandi, G. Evangelisti, A. Qalqili

Research output: Contribution to journalArticlepeer-review


We refer a case of a patient affected by a grave form of TTP, that arrived to our observation in coma and that was treated with infusions of frozen fresh plasma, daily plasma exchange, prednisolone and antiaggregants, for a period of two months. During this period the result was the awakening of the patient from the comatose state, however the interruption of the treatment was soon followed by a relapse of most of the symptoms. The patient showed a complete clinical remission after one month of immunosuppressive treatment with cyclosporine. After three months the patient was discharged with a reduced dosage of cyclosporine, subsequently however, he suffered three brief relapses, which necessitated ulterior infusions of frozen fresh plasma. The therapy was suspended after 10 months and the patient presently shows a good state of health.

Original languageEnglish
Pages (from-to)81-83
Number of pages3
JournalMedecine Biologie Environment
Issue number1
Publication statusPublished - 1997


  • Cyclosporine
  • Thrombotic thrombocytopenic purpura
  • TTP treatment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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