Thrombotic thrombocytopenic purpura and related disorders

P. Ruggenenti, G. Remuzzi

Research output: Contribution to journalArticlepeer-review


This article provides us with background information on the disease. Clinical features, variants and classification, laboratory findings, and pathology are discussed. Knowledge of the disease's pathogenesis has increased recently and specific causes discussed are predisposing factors, triggering agents, endothelial damage, defective PGI2 bioavailability, FVIII/vWF multimeric structure abnormalities, platelet activation, and hemolytic anemia. Proposed specific therapies discussed are steroids, heparin, antiplatelet agents, prostacyclin, splenectomy, immunosuppressive agents, plasma infusion, and plasma exchange.

Original languageEnglish
Pages (from-to)219-241
Number of pages23
JournalHematology/Oncology Clinics of North America
Issue number1
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Hematology
  • Oncology


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