Abstract
A correlation between increased platelet adhesiveness and aggregation and the development of angiopathy in diabetes mellitus can be made. Thromboxane produced by platelets represents a potent platelet aggregation factor. We studied the platelet TXB2 production during blood coagulation in carefully selected patients with type II diabetes mellitus in good metabolic control and the results were correlated with the presence or absence of microangiopathy, fasting blood glucose levels, type of therapy, age, duration of diabetes and the most important hematochemical parameters. No statistically significant differences were found between serum TXB2 concentrations in diabetic patients and control subjects, in diabetics with or without microangiopathy and in diabetics on insulin therapy or on oral hypoglycemic agents. We did not observe any correlation between TXB2 production and age, duration of diabetes, sex, basal blood glucose levels, total and HDL-cholesterol, triglycerides, blood creatinine and blood electrolytes. The thromboxane production may be a not important factor for determining the increased platelet aggregation which is at the origin of the angiopathy in diabetes mellitus.
| Original language | English |
|---|---|
| Pages (from-to) | 539-542 |
| Number of pages | 4 |
| Journal | La Ricerca in Clinica e in Laboratorio |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 1986 |
Fingerprint
Keywords
- Diabetes mellitus
- Microangiopathy
- Platelets
- Thromboxane
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Thromboxane production in diabetes mellitus. / Altomonte, Lorenzo; Zoli, Angelo; Mangia, Alessandra; Ghirlanda, Giovanni; Manna, Raffaele; Bertoli, Aldo; Greco, Aldo Virgilio.
In: La Ricerca in Clinica e in Laboratorio, Vol. 16, No. 4, 10.1986, p. 539-542.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thromboxane production in diabetes mellitus
AU - Altomonte, Lorenzo
AU - Zoli, Angelo
AU - Mangia, Alessandra
AU - Ghirlanda, Giovanni
AU - Manna, Raffaele
AU - Bertoli, Aldo
AU - Greco, Aldo Virgilio
PY - 1986/10
Y1 - 1986/10
N2 - A correlation between increased platelet adhesiveness and aggregation and the development of angiopathy in diabetes mellitus can be made. Thromboxane produced by platelets represents a potent platelet aggregation factor. We studied the platelet TXB2 production during blood coagulation in carefully selected patients with type II diabetes mellitus in good metabolic control and the results were correlated with the presence or absence of microangiopathy, fasting blood glucose levels, type of therapy, age, duration of diabetes and the most important hematochemical parameters. No statistically significant differences were found between serum TXB2 concentrations in diabetic patients and control subjects, in diabetics with or without microangiopathy and in diabetics on insulin therapy or on oral hypoglycemic agents. We did not observe any correlation between TXB2 production and age, duration of diabetes, sex, basal blood glucose levels, total and HDL-cholesterol, triglycerides, blood creatinine and blood electrolytes. The thromboxane production may be a not important factor for determining the increased platelet aggregation which is at the origin of the angiopathy in diabetes mellitus.
AB - A correlation between increased platelet adhesiveness and aggregation and the development of angiopathy in diabetes mellitus can be made. Thromboxane produced by platelets represents a potent platelet aggregation factor. We studied the platelet TXB2 production during blood coagulation in carefully selected patients with type II diabetes mellitus in good metabolic control and the results were correlated with the presence or absence of microangiopathy, fasting blood glucose levels, type of therapy, age, duration of diabetes and the most important hematochemical parameters. No statistically significant differences were found between serum TXB2 concentrations in diabetic patients and control subjects, in diabetics with or without microangiopathy and in diabetics on insulin therapy or on oral hypoglycemic agents. We did not observe any correlation between TXB2 production and age, duration of diabetes, sex, basal blood glucose levels, total and HDL-cholesterol, triglycerides, blood creatinine and blood electrolytes. The thromboxane production may be a not important factor for determining the increased platelet aggregation which is at the origin of the angiopathy in diabetes mellitus.
KW - Diabetes mellitus
KW - Microangiopathy
KW - Platelets
KW - Thromboxane
UR - http://www.scopus.com/inward/record.url?scp=0022789130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022789130&partnerID=8YFLogxK
U2 - 10.1007/BF02886836
DO - 10.1007/BF02886836
M3 - Article
C2 - 3576051
AN - SCOPUS:0022789130
VL - 16
SP - 539
EP - 542
JO - Ricerca in Clinica e in Laboratorio
JF - Ricerca in Clinica e in Laboratorio
SN - 0940-5437
IS - 4
ER -