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Imagined hand movements counteract the adverse effects of post-surgical hand immobilization. Clinical, behavioral, and fMRI longitudinal observations

Martina Gandola, Laura Zapparoli, Gianluca Saetta, Antonio De Santis, Alberto Zerbi, Giuseppe Banfi, Valerio Sansone, Maurilio Bruno, Eraldo Paulesu

Research output: Contribution to journalArticle

Abstract

Motor imagery (M.I.) training has been widely used to enhance motor behavior. To characterize the neural foundations of its rehabilitative effects in a pathological population we studied twenty-two patients with rhizarthrosis, a chronic degenerative articular disease in which thumb-to-fingers opposition becomes difficult due to increasing pain while the brain is typically intact. Before and after surgery, patients underwent behavioral tests to measure pain and motor performance and fMRI measurements of brain motor activity. After surgery, the affected hand was immobilized, and patients were enrolled in a M.I. training. The sample was split in those who had a high compliance with the program of scheduled exercises (T+, average compliance: 84%) and those with low compliance (T−, average compliance: 20%; cut-off point: 55%). We found that more intense M.I. training counteracts the adverse effects of immobilization reducing pain and expediting motor recovery. fMRI data from the post-surgery session showed that T+ patients had decreased brain activation in the premotor cortex and the supplementary motor area (SMA); meanwhile, for the same movements, the T− patients exhibited a reversed pattern. Furthermore, in the post-surgery fMRI session, pain intensity was correlated with activity in the ipsilateral precentral gyrus and, notably, in the insular cortex, a node of the pain matrix. These findings indicate that the motor simulations of M.I. have a facilitative effect on recovery by cortical plasticity mechanisms and optimization of motor control, thereby establishing the rationale for incorporating the systematic use of M.I. into standard rehabilitation for the management of post-immobilization syndromes characteristic of hand surgery.

Original languageEnglish
Article number101838
JournalNeuroImage: Clinical
Volume23
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Imagery (Psychotherapy)
Immobilization
Hand
Magnetic Resonance Imaging
Pain
Compliance
Motor Cortex
Brain
Thumb
Frontal Lobe
Cerebral Cortex
Fingers
Motor Activity
Rehabilitation
Joints
Exercise
Population

Keywords

  • Brain plasticity
  • Mental imagery training
  • Rhizarthrosis
  • Trapeziometacarpal joint osteoarthritis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Thumbs up : Imagined hand movements counteract the adverse effects of post-surgical hand immobilization. Clinical, behavioral, and fMRI longitudinal observations. / Gandola, Martina; Zapparoli, Laura; Saetta, Gianluca; De Santis, Antonio; Zerbi, Alberto; Banfi, Giuseppe; Sansone, Valerio; Bruno, Maurilio; Paulesu, Eraldo.

In: NeuroImage: Clinical, Vol. 23, 101838, 01.01.2019.

Research output: Contribution to journalArticle

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