Thymic function recovery after unrelated donor cord blood or T-cell depleted HLA-haploidentical stem cell transplantation correlates with leukemia relapse

Emmanuel Clave, Daniela Lisini, Corinne Douay, Giovanna Giorgiani, Marc Busson, Marco Zecca, Francesca Moretta, Gloria Acquafredda, Letizia P. Brescia, Franco Locatelli, Antoine Toubert

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Abstract

Use of alternative donors/sources of hematopoietic stem cells (HSC), such as cord blood (CB) or HLA-haploidentical (Haplo)-related donors, is associated with a significant delay in immune reconstitution after transplantation. Long-term T-cell immune reconstitution largely relies on the generation of new T cells in the recipient thymus, which can be evaluated through signal joint (sj) and beta T-cell-Receptor Excision Circles (TREC) quantification. We studied two groups of 33 and 24 children receiving, respectively, HSC Transplantation (HSCT) from an HLA-haploidentical family donor or an unrelated CB donor, for both malignant (46) and non-malignant disorders (11). Relative and absolute sj and beta-TREC values indicated comparable thymic function reconstitution at 3 and 6 months after the allograft in both groups. Compared to children with non-malignant disorders, those with hematological malignancies had significantly lower pre-transplantation TREC counts. Patients who relapsed after HSCT had a significantly less efficient thymic function both before and 6 months after HSCT with especially low beta-TREC values, this finding suggesting an impact of early intra-thymic T-cell differentiation on the occurrence of leukemia relapse.

Original languageEnglish
Article numberArticle 54
JournalFrontiers in Immunology
Volume4
Issue numberMAR
DOIs
Publication statusPublished - 2013

Fingerprint

Unrelated Donors
Recovery of Function
Stem Cell Transplantation
T-Cell Antigen Receptor
Fetal Blood
Leukemia
Transplantation
T-Lymphocytes
Recurrence
Joints
Tissue Donors
Hematopoietic Stem Cell Transplantation
Hematologic Neoplasms
Hematopoietic Stem Cells
Blood Donors
Thymus Gland
Allografts
Cell Differentiation

Keywords

  • HSCT
  • Leukemia
  • Relapse
  • T cells
  • Thymic function

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

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title = "Thymic function recovery after unrelated donor cord blood or T-cell depleted HLA-haploidentical stem cell transplantation correlates with leukemia relapse",
abstract = "Use of alternative donors/sources of hematopoietic stem cells (HSC), such as cord blood (CB) or HLA-haploidentical (Haplo)-related donors, is associated with a significant delay in immune reconstitution after transplantation. Long-term T-cell immune reconstitution largely relies on the generation of new T cells in the recipient thymus, which can be evaluated through signal joint (sj) and beta T-cell-Receptor Excision Circles (TREC) quantification. We studied two groups of 33 and 24 children receiving, respectively, HSC Transplantation (HSCT) from an HLA-haploidentical family donor or an unrelated CB donor, for both malignant (46) and non-malignant disorders (11). Relative and absolute sj and beta-TREC values indicated comparable thymic function reconstitution at 3 and 6 months after the allograft in both groups. Compared to children with non-malignant disorders, those with hematological malignancies had significantly lower pre-transplantation TREC counts. Patients who relapsed after HSCT had a significantly less efficient thymic function both before and 6 months after HSCT with especially low beta-TREC values, this finding suggesting an impact of early intra-thymic T-cell differentiation on the occurrence of leukemia relapse.",
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author = "Emmanuel Clave and Daniela Lisini and Corinne Douay and Giovanna Giorgiani and Marc Busson and Marco Zecca and Francesca Moretta and Gloria Acquafredda and Brescia, {Letizia P.} and Franco Locatelli and Antoine Toubert",
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T1 - Thymic function recovery after unrelated donor cord blood or T-cell depleted HLA-haploidentical stem cell transplantation correlates with leukemia relapse

AU - Clave, Emmanuel

AU - Lisini, Daniela

AU - Douay, Corinne

AU - Giorgiani, Giovanna

AU - Busson, Marc

AU - Zecca, Marco

AU - Moretta, Francesca

AU - Acquafredda, Gloria

AU - Brescia, Letizia P.

AU - Locatelli, Franco

AU - Toubert, Antoine

PY - 2013

Y1 - 2013

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