It has been previously shown that the thymus regulates the pharmacologically induced increase of [3H]-thymidine (Tdr) incorporation into DNA of submandibular glands (SG) of mice. In order to test whether the thymic control can also be manifested during physiological body growth, we compared Tdr incorporation into DNA of SG from normal, nude and thymus-grafted nude mice during development. Until about 20 days of age nude mice showed a lower rate of Tdr incorporation when compared to their normal littermates. Afterwards, the difference disappeared. No differences in body weight were found between nude and haired littermates in the period considered. Since the alteration can be corrected by a neonatal thymus grafted into nude recipients, the possibility can be excluded that the alteration might be due to the pleiotropic effect of nude mutation and not to the aplasia of the thymus per se.
|Number of pages||2|
|Journal||IRCS Medical Science|
|Publication status||Published - 1984|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)