Thymic regulation of brain cortex beta-adrenoceptors during development and aging

Lucio Piantanelli, Simonetta Gentile, Patrizia Fattoretti, Claudio Viticchi

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of the thymus on beta-adrenoceptors has been studied in the brain cortex of mice during developing and aging. Affinity of beta-adrenoceptors shows no statistically significant changes in the various animal models investigated. Receptor density shows a fall in both athymic nude mice and in old normal mice. Receptor density, in particular, decreases progressively with advancing age. It has been demonstrated that thymus exerts a regulatory role in both development and aging, as a neonatal thymic graft is capable of reversing the receptor impairments found in young athymic nude mice and in old normal mice.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalArchives of Gerontology and Geriatrics
Volume4
Issue number2
DOIs
Publication statusPublished - 1985

Keywords

  • aging
  • beta-adrenoceptors
  • brain cortex
  • development
  • thymus

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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