Abstract
Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.
| Original language | English |
|---|---|
| Pages (from-to) | 2219-2221 |
| Number of pages | 3 |
| Journal | AIDS (London, England) |
| Volume | 16 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - Nov 8 2002 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy. / Clerici, Mario; Saresella, Marina; Trabattoni, Daria; Ferrante, Pasquale; Vanzulli, Angelo; Vigano, Alessandra.
In: AIDS (London, England), Vol. 16, No. 16, 08.11.2002, p. 2219-2221.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy
AU - Clerici, Mario
AU - Saresella, Marina
AU - Trabattoni, Daria
AU - Ferrante, Pasquale
AU - Vanzulli, Angelo
AU - Vigano, Alessandra
PY - 2002/11/8
Y1 - 2002/11/8
N2 - Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.
AB - Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.
UR - http://www.scopus.com/inward/record.url?scp=0037045057&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037045057&partnerID=8YFLogxK
U2 - 10.1097/00002030-200211080-00015
DO - 10.1097/00002030-200211080-00015
M3 - Article
C2 - 12409744
AN - SCOPUS:0037045057
VL - 16
SP - 2219
EP - 2221
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 16
ER -