Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy

Mario Clerici, Marina Saresella, Daria Trabattoni, Pasquale Ferrante, Angelo Vanzulli, Alessandra Vigano

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.

Original languageEnglish
Pages (from-to)2219-2221
Number of pages3
JournalAIDS (London, England)
Volume16
Issue number16
DOIs
Publication statusPublished - Nov 8 2002

Fingerprint

Highly Active Antiretroviral Therapy
HIV
CD4 Lymphocyte Count
Thymus Gland
T-Lymphocytes
Phenotype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy. / Clerici, Mario; Saresella, Marina; Trabattoni, Daria; Ferrante, Pasquale; Vanzulli, Angelo; Vigano, Alessandra.

In: AIDS (London, England), Vol. 16, No. 16, 08.11.2002, p. 2219-2221.

Research output: Contribution to journalArticle

Clerici, Mario ; Saresella, Marina ; Trabattoni, Daria ; Ferrante, Pasquale ; Vanzulli, Angelo ; Vigano, Alessandra. / Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy. In: AIDS (London, England). 2002 ; Vol. 16, No. 16. pp. 2219-2221.
@article{718ccfeb7b8242f0a1257e1cb918f769,
title = "Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy",
abstract = "Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.",
author = "Mario Clerici and Marina Saresella and Daria Trabattoni and Pasquale Ferrante and Angelo Vanzulli and Alessandra Vigano",
year = "2002",
month = "11",
day = "8",
doi = "10.1097/00002030-200211080-00015",
language = "English",
volume = "16",
pages = "2219--2221",
journal = "AIDS",
issn = "0269-9370",
publisher = "NLM (Medline)",
number = "16",

}

TY - JOUR

T1 - Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy

AU - Clerici, Mario

AU - Saresella, Marina

AU - Trabattoni, Daria

AU - Ferrante, Pasquale

AU - Vanzulli, Angelo

AU - Vigano, Alessandra

PY - 2002/11/8

Y1 - 2002/11/8

N2 - Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.

AB - Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.

UR - http://www.scopus.com/inward/record.url?scp=0037045057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037045057&partnerID=8YFLogxK

U2 - 10.1097/00002030-200211080-00015

DO - 10.1097/00002030-200211080-00015

M3 - Article

C2 - 12409744

AN - SCOPUS:0037045057

VL - 16

SP - 2219

EP - 2221

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 16

ER -