Abstract
Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.
| Original language | English |
|---|---|
| Pages (from-to) | 2219-2221 |
| Number of pages | 3 |
| Journal | AIDS (London, England) |
| Volume | 16 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - Nov 8 2002 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Clerici, M., Saresella, M., Trabattoni, D., Ferrante, P., Vanzulli, A., & Vigano, A. (2002). Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy. AIDS (London, England), 16(16), 2219-2221. https://doi.org/10.1097/00002030-200211080-00015