Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy

Mario Clerici, Marina Saresella, Daria Trabattoni, Pasquale Ferrante, Angelo Vanzulli, Alessandra Vigano

Research output: Contribution to journalArticle

Abstract

Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.

Original languageEnglish
Pages (from-to)2219-2221
Number of pages3
JournalAIDS (London, England)
Volume16
Issue number16
DOIs
Publication statusPublished - Nov 8 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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