Thymidine phosphorylase profiles in nonmalignant and malignant pancreatic tissue. Potential therapeutic role of capecitabine on tumoral and endothelial cells and tumor-infiltrating macrophages

L. Passantino, R. Patruno, P. Valerio, A. Penna, F. Mazzone, A. F. Zito, V. Catalano, A. Pellecchia, E. Jirillo, Girolamo Ranieri

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The drug capecitabine (CAP) is a thymidine Pi-deoxyribosyltransferase (TP) activated oral fluorpyrimidine that generates 5-fluorouracil (5-FU), prefentially, within tumors. Here, in 38 patients with pancreatic cancer we analyzed immunohistochemical TP expression in pancreatic cancer tissue (PCT) and adjacent nonmalignant pancreatic tissue (ANMPT). In addition, a correlation with the main clinical pathological features was made. Furthermore, TP-positive macrophages (MØ) isolated from neoplastic tissue were determined. The mean of TP-positive epithelial cells and endothelial cells in terms of microvessel density was significantly higher in PCT than in ANMPT. Because pancreatic cancer is sensitive to 5-FU, TP-activated oral CAP in tumoral and endothelial cells and tumor infiltrating MØ could increase the concentration of 5-FU at tumor site, thus resulting in an enhanced antitumor activity.

Original languageEnglish
Pages (from-to)95-107
Number of pages13
JournalImmunopharmacology and Immunotoxicology
Volume27
Issue number1
DOIs
Publication statusPublished - 2005

Fingerprint

Thymidine Phosphorylase
Macrophages
Endothelial cells
Thymidine
Tumors
Pancreatic Neoplasms
Endothelial Cells
Tissue
Fluorouracil
Neoplasms
Therapeutics
Microvessels
Epithelial Cells
Capecitabine
Pharmaceutical Preparations

Keywords

  • 5-Fluorouracile
  • Capecitabine
  • Immunohistochemistry
  • Pancreatic cancer
  • Platelet-derived endothelial cell growth factor
  • Thymidine phosphorylase

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Thymidine phosphorylase profiles in nonmalignant and malignant pancreatic tissue. Potential therapeutic role of capecitabine on tumoral and endothelial cells and tumor-infiltrating macrophages. / Passantino, L.; Patruno, R.; Valerio, P.; Penna, A.; Mazzone, F.; Zito, A. F.; Catalano, V.; Pellecchia, A.; Jirillo, E.; Ranieri, Girolamo.

In: Immunopharmacology and Immunotoxicology, Vol. 27, No. 1, 2005, p. 95-107.

Research output: Contribution to journalArticle

Passantino, L. ; Patruno, R. ; Valerio, P. ; Penna, A. ; Mazzone, F. ; Zito, A. F. ; Catalano, V. ; Pellecchia, A. ; Jirillo, E. ; Ranieri, Girolamo. / Thymidine phosphorylase profiles in nonmalignant and malignant pancreatic tissue. Potential therapeutic role of capecitabine on tumoral and endothelial cells and tumor-infiltrating macrophages. In: Immunopharmacology and Immunotoxicology. 2005 ; Vol. 27, No. 1. pp. 95-107.
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abstract = "The drug capecitabine (CAP) is a thymidine Pi-deoxyribosyltransferase (TP) activated oral fluorpyrimidine that generates 5-fluorouracil (5-FU), prefentially, within tumors. Here, in 38 patients with pancreatic cancer we analyzed immunohistochemical TP expression in pancreatic cancer tissue (PCT) and adjacent nonmalignant pancreatic tissue (ANMPT). In addition, a correlation with the main clinical pathological features was made. Furthermore, TP-positive macrophages (M{\O}) isolated from neoplastic tissue were determined. The mean of TP-positive epithelial cells and endothelial cells in terms of microvessel density was significantly higher in PCT than in ANMPT. Because pancreatic cancer is sensitive to 5-FU, TP-activated oral CAP in tumoral and endothelial cells and tumor infiltrating M{\O} could increase the concentration of 5-FU at tumor site, thus resulting in an enhanced antitumor activity.",
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AU - Penna, A.

AU - Mazzone, F.

AU - Zito, A. F.

AU - Catalano, V.

AU - Pellecchia, A.

AU - Jirillo, E.

AU - Ranieri, Girolamo

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