Thymoma and inter-relationships between clinical variables: A multicentre study in 537 patients

Pier Luigi Filosso, Federico Venuta, Alberto Oliaro, Enrico Ruffini, Erino Angelo Rendina, Stefano Margaritora, Caterina Casadio, Alberto Terzi, Ottavio Rena, Filippo Lococo, Francesco Guerrera

Research output: Contribution to journalArticlepeer-review


OBJECTIVES: In thymomas, the roles of Masaoka-Koga stage, histology and the presence of myasthenia gravis (MG) have been considered fundamental for patient management and outcomes. In this study, we retrospectively evaluated several clinical variables, with the aim of outlining their relationships and clinical/prognostic significance in resected thymoma patients. METHODS: A retrospective search of our surgical database for patients operated on for thymoma in six Italian high-volume thoracic surgery centres between 2000 and 2011 was conducted. The following clinical variables were evaluated: Masaoka-Koga Stage, tumour histology, the presence of MG, other autoimmune syndromes or second tumours, the completeness of tumour resection and the development of recurrences. RESULTS: Five hundred and thirty-seven (273 males-51%) were retrospectively included in this study. Our results indicate that: (i) MG correlates with early Masaoka-Koga stage and B-type thymoma; (ii) Stage III-IVa tumours correlate with B-type tumour; (iii) autoimmune paraneoplastic syndromes correlate with Stage I-II thymoma; (iv) second malignancies correlate with the absence of paraneoplastic disorders and weakly with B-type tumour and (v) overall survival was influenced by Masaoka-Koga stage and completeness of surgical resection. CONCLUSIONS: In thymomas, Masaoka-Koga stage, histology, MG, other autoimmune syndromes and second malignancies are inter-related, but only Masaoka-Koga tumour stage, amid these clinical variables, has been demonstrated to be a strong prognostic indicator of survival.

Original languageEnglish
Article numberezt567
Pages (from-to)1020-1027
Number of pages8
JournalEuropean Journal of Cardio-thoracic Surgery
Issue number6
Publication statusPublished - 2014


  • Cancer
  • Myasthenia gravis
  • Paraneoplastic disorders
  • Pathology
  • Surgery
  • Thymoma
  • World Health Organization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine
  • Medicine(all)


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