Thymoma and thymic carcinoma - Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus

Mirella Marino, Hans Konrad Müller-Hermelink

Research output: Contribution to journalArticle

Abstract

Based on the light microscopical features of normal thymic epithelial cells, human thymoma was divided in different types, namely cortical, medullary, and mixed ones, according to the epithelial cell (EC) type. Lymphoid cell populations with morphological features of either cortical or medullary thymocytes were found according to different types of EC in thymoma. The histological variation of the different types of thymoma are demonstrated. In a retrospective study of 58 thymomas and 13 thymic carcinomas, malignant invasive character as well as the occurrence of myasthenia gravis were both found to be related to the neoplastic proliferation of the cortical epithelial cells, whereas in the usual mixed type of thymoma and the medullary type no gross invasion or metastases were noticed. These results are discussed in view of recent concepts and immunological findings of thymus microarchitecture.

Original languageEnglish
Pages (from-to)119-149
Number of pages31
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Volume407
Issue number2
DOIs
Publication statusPublished - Aug 1985

Keywords

  • Myasthenia gravis
  • Thymoma
  • Thymus epithelial cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy

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