Thymoma-associated myasthenia gravis: Outcome, clinical and pathological correlations in 197 patients on a 20-year experience

Lorenzo Maggi, Francesca Andreetta, Carlo Antozzi, Fulvio Baggi, Pia Bernasconi, Paola Cavalcante, Ferdinando Cornelio, Giuseppe Muscolino, Lorenzo Novellino, Renato Mantegazza

Research output: Contribution to journalArticlepeer-review

Abstract

We studied 197 patients with thymoma-associated myasthenia gravis (T-MG) to identify variables that can influence the natural history of the disease and the therapeutical approaches. Multivariate analysis showed that neither clinical nor pathological variables were associated with a better chance to reach complete stable remission. The video-assisted thoracoscopic extended thymectomy (VATET) was not significantly correlated with a lower chance of achieving complete stable remission compared with the classical transsternal approach (T-3b) (p = 0.1090). Thymoma recurrence was not correlated with surgery by VATET or T-3b. VATET was safe and reliable for removal of thymoma. The low chance of achieving remission (9.64%) in T-MG underlines the importance of an early diagnosis as well as the need for more aggressive therapeutic strategies.

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalJournal of Neuroimmunology
Volume201-202
Issue numberC
DOIs
Publication statusPublished - Sep 15 2008

Keywords

  • Myasthenia gravis
  • Thymoma
  • Thymomectomy
  • VATET

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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