TY - JOUR
T1 - Thymoma-associated myasthenia gravis
T2 - Outcome, clinical and pathological correlations in 197 patients on a 20-year experience
AU - Maggi, Lorenzo
AU - Andreetta, Francesca
AU - Antozzi, Carlo
AU - Baggi, Fulvio
AU - Bernasconi, Pia
AU - Cavalcante, Paola
AU - Cornelio, Ferdinando
AU - Muscolino, Giuseppe
AU - Novellino, Lorenzo
AU - Mantegazza, Renato
PY - 2008/9/15
Y1 - 2008/9/15
N2 - We studied 197 patients with thymoma-associated myasthenia gravis (T-MG) to identify variables that can influence the natural history of the disease and the therapeutical approaches. Multivariate analysis showed that neither clinical nor pathological variables were associated with a better chance to reach complete stable remission. The video-assisted thoracoscopic extended thymectomy (VATET) was not significantly correlated with a lower chance of achieving complete stable remission compared with the classical transsternal approach (T-3b) (p = 0.1090). Thymoma recurrence was not correlated with surgery by VATET or T-3b. VATET was safe and reliable for removal of thymoma. The low chance of achieving remission (9.64%) in T-MG underlines the importance of an early diagnosis as well as the need for more aggressive therapeutic strategies.
AB - We studied 197 patients with thymoma-associated myasthenia gravis (T-MG) to identify variables that can influence the natural history of the disease and the therapeutical approaches. Multivariate analysis showed that neither clinical nor pathological variables were associated with a better chance to reach complete stable remission. The video-assisted thoracoscopic extended thymectomy (VATET) was not significantly correlated with a lower chance of achieving complete stable remission compared with the classical transsternal approach (T-3b) (p = 0.1090). Thymoma recurrence was not correlated with surgery by VATET or T-3b. VATET was safe and reliable for removal of thymoma. The low chance of achieving remission (9.64%) in T-MG underlines the importance of an early diagnosis as well as the need for more aggressive therapeutic strategies.
KW - Myasthenia gravis
KW - Thymoma
KW - Thymomectomy
KW - VATET
UR - http://www.scopus.com/inward/record.url?scp=51849100206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51849100206&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2008.07.012
DO - 10.1016/j.jneuroim.2008.07.012
M3 - Article
C2 - 18722676
AN - SCOPUS:51849100206
VL - 201-202
SP - 237
EP - 244
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - C
ER -