Thymoma associated with myasthenia and autonomic anti-Hu paraneoplastic neuropathy

Matteo Simonelli, Giuseppe Luigi Banna, Armando Santoro

Research output: Contribution to journalArticlepeer-review


Along with myasthenia, other paraneoplastic neurological syndromes (PNS) may occur in thymoma. Anti-Hu antibodies and a clinical "anti-Hu syndrome" characterized by encephalitis and/or painful neuropathies have been reported in only three patients at the time of the diagnosis of thymoma. We describe a severe anti-Hu-related autonomic neuropathy with gastrointestinal paresis and intestinal pseudo-obstruction with malabsorption that occurred concomitantly with the worsening of myas-thenic symptoms long after the initial diagnosis of thymoma in a young patient. The clinical anti-Hu syndrome preceded the radiological diagnosis of thymoma recurrence. Treatment with plasma exchange led to a transient improvement of neurological symptoms.

Original languageEnglish
Pages (from-to)243-247
Number of pages5
Issue number2
Publication statusPublished - Mar 2009


  • Anti-Hu
  • Autonomic neuropathy
  • Myasthenia
  • Paraneoplastic neurological syndrome
  • Thymoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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