Thymoma followed by paroxysmal nocturnal hemoglobinuria: A unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes

Giovannella Palmieri, Carmine Selleri, Liliana Montella, Goffredo Bulgarelli, Laura Vitiello, Ghassan Merkabaoui, Patrizia Ricci, Luigi Del Vecchio, Annamaria Masci, Luigi Racioppi, Bruno Rotoli

Research output: Contribution to journalArticle

Abstract

Seven years after a surgically resected thymoma, a female patient affected by myasthenia gravis and Good's syndrome presented with paroxysmal nocturnal hemoglobinuria (PNH). Co-culture experiments and spectratyping analyses indicated that CD8+ lymphocytes were involved in damaging hematopoietic precursors. While PNH clones have been identified in various hematological disorders, the sequential association of thymoma and PNH has been unreported so far.

Original languageEnglish
Pages (from-to)774-778
Number of pages5
JournalAmerican Journal of Hematology
Volume81
Issue number10
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Autoimmunity
  • Paroxysmal nocturnal hemoglobinuria
  • Thymoma

ASJC Scopus subject areas

  • Hematology

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    Palmieri, G., Selleri, C., Montella, L., Bulgarelli, G., Vitiello, L., Merkabaoui, G., Ricci, P., Del Vecchio, L., Masci, A., Racioppi, L., & Rotoli, B. (2006). Thymoma followed by paroxysmal nocturnal hemoglobinuria: A unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes. American Journal of Hematology, 81(10), 774-778. https://doi.org/10.1002/ajh.20699