Thymomodulin stimulates phagocytosis in vitro by rat macrophages and human polymorphonuclear cells

P. C. Braga, G. Piatti, M. Dal Sasso, S. Maci, F. Blasi

Research output: Contribution to journalArticlepeer-review

Abstract

Activation of non-specific host defenses can increase resistance to infection in patients and especially those with reduced immune response. Thymomodulin is a calf thymic derivative containing low molecular weight peptides, which exerts immunomodulating activity probably through an enhancement of lymphocyte functions. To explore this possibility, rat macrophages (MP) and human polymorphonuclear (HPMN) cells were incubated in vitro with 100, 200, 400 μg/ml of thymomodulin at 37° C for 60 min and their phagocytic activity was investigated. The number of phagocytosing cells was significantly increased following increasing concentrations of thymomodulin and the percentage of phagocytosis was increased more for human PMNs in comparison with rat MP, while the values of the phagocytic index were not modified after challenge with thymomodulin both for MPs and HPMNs.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalJournal of Chemotherapy
Volume5
Issue number5
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

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