TY - JOUR
T1 - Thymosin α 1 potentiates interleukin 2-induced cytotoxic activity in mice
AU - Mastino, Antonio
AU - Favalli, Cartesio
AU - Grelli, Sandro
AU - Innocenti, Fabrizia
AU - Garaci, Enrico
PY - 1991
Y1 - 1991
N2 - We have investigated the effects of interleukin 2 (IL-2) on cytotoxic activity of spleen lymphocytes, from normal and cyclophosphamide (200 mg/kg) or B-16 melanoma suppressed mice, after in vitro or in vivo pretreatment with thymosin α 1 (TA1). The results of this study indicate that pretreatment in vitro (100 ng/ml for 1 hr) or in vivo (200 μg/kg/day for 4 days) with thymosin α 1 (TA1), significantly increased the IL-2 (from 100 to 500 U/ml) in vitro induced cytotoxic activity of spleen lymphocytes, collected from both normal and cyclophosphamide and tumor-suppressed animals, against both YAC-1 (NK sensitive) and MBL-2 (NK resistant) cell lines. The potential use in combination of these two different biological response modifiers, useful in enhancing the immunological responses to IL-2 of lymphocytes, may provide a novel model of immunotherapeutic intervention in cancer.
AB - We have investigated the effects of interleukin 2 (IL-2) on cytotoxic activity of spleen lymphocytes, from normal and cyclophosphamide (200 mg/kg) or B-16 melanoma suppressed mice, after in vitro or in vivo pretreatment with thymosin α 1 (TA1). The results of this study indicate that pretreatment in vitro (100 ng/ml for 1 hr) or in vivo (200 μg/kg/day for 4 days) with thymosin α 1 (TA1), significantly increased the IL-2 (from 100 to 500 U/ml) in vitro induced cytotoxic activity of spleen lymphocytes, collected from both normal and cyclophosphamide and tumor-suppressed animals, against both YAC-1 (NK sensitive) and MBL-2 (NK resistant) cell lines. The potential use in combination of these two different biological response modifiers, useful in enhancing the immunological responses to IL-2 of lymphocytes, may provide a novel model of immunotherapeutic intervention in cancer.
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U2 - 10.1016/0008-8749(91)90191-D
DO - 10.1016/0008-8749(91)90191-D
M3 - Article
C2 - 1991327
AN - SCOPUS:0026092975
VL - 133
SP - 196
EP - 205
JO - Cellular Immunology
JF - Cellular Immunology
SN - 0008-8749
IS - 1
ER -