Thymosin α1: A historical overview

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Thymosin α 1 (Tα1), initially isolated from thymus, was characterized by Allan Goldstein in 1977. Since the beginning, our studies were aimed at evaluating its immunomodulating effects when used in combination with cytokines and chemotherapy. Combination therapies have now proved to be effective in inhibiting tumoral growth and in controlling infective diseases especially in the immunocompromised host. More recent studies showed that Tα1 molecule increased major histocompatibility complex (MHC) class-1 and Toll-like receptor expression as well as cytokine production, suggesting its immunoregulatory role. Overall these results led us to start pilot clinical trials on patients with hepatitis C and cancer.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages7
Publication statusPublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • Combination therapies
  • Thymosin α1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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