Abstract
Since it was first identified, thymosin alpha 1 (Tα1) has been characterized to have pleiotropic effects on several pathological conditions, in particular as a modulator of immune response and inflammation. Several properties exerted by Tα1 may be attributable to a direct action on lymphoid cells. Tα1 has been shown to exert an immune modulatory activity on both T cell and natural killer cell maturation and to have an effect on functions of mature lymphocytes, including stimulating cytokine production and cytotoxic T lymphocyte-mediated cytotoxic responses. In previous studies we have shown that Tα1 increases the expression of major histocompatibility complex class I surface molecules in murine and human tumor cell lines and in primary cultures of human macrophages. In the present paper, we describe preliminary data indicating that Tα1 is also capable of increasing the expression of tumor antigens in both experimental and human tumor cell lines. This effect, which is exerted at the level of the target tumor cells, represents an additional factor increasing the antitumor activity of Tα1.
| Original language | English |
|---|---|
| Pages (from-to) | 26-33 |
| Number of pages | 8 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1269 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 2012 |
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Keywords
- Cancer
- Immune effector cells
- Thymosin α1
- Tumor antigens
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
Thymosin α1 and cancer : Action on immune effector and tumor target cells. / Garaci, Enrico; Pica, Francesca; Serafino, Annalucia; Balestrieri, Emanuela; Matteucci, Claudia; Moroni, Gabriella; Sorrentino, Roberta; Zonfrillo, Manuela; Pierimarchi, Pasquale; Sinibaldi-Vallebona, Paola.
In: Annals of the New York Academy of Sciences, Vol. 1269, No. 1, 10.2012, p. 26-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thymosin α1 and cancer
T2 - Action on immune effector and tumor target cells
AU - Garaci, Enrico
AU - Pica, Francesca
AU - Serafino, Annalucia
AU - Balestrieri, Emanuela
AU - Matteucci, Claudia
AU - Moroni, Gabriella
AU - Sorrentino, Roberta
AU - Zonfrillo, Manuela
AU - Pierimarchi, Pasquale
AU - Sinibaldi-Vallebona, Paola
PY - 2012/10
Y1 - 2012/10
N2 - Since it was first identified, thymosin alpha 1 (Tα1) has been characterized to have pleiotropic effects on several pathological conditions, in particular as a modulator of immune response and inflammation. Several properties exerted by Tα1 may be attributable to a direct action on lymphoid cells. Tα1 has been shown to exert an immune modulatory activity on both T cell and natural killer cell maturation and to have an effect on functions of mature lymphocytes, including stimulating cytokine production and cytotoxic T lymphocyte-mediated cytotoxic responses. In previous studies we have shown that Tα1 increases the expression of major histocompatibility complex class I surface molecules in murine and human tumor cell lines and in primary cultures of human macrophages. In the present paper, we describe preliminary data indicating that Tα1 is also capable of increasing the expression of tumor antigens in both experimental and human tumor cell lines. This effect, which is exerted at the level of the target tumor cells, represents an additional factor increasing the antitumor activity of Tα1.
AB - Since it was first identified, thymosin alpha 1 (Tα1) has been characterized to have pleiotropic effects on several pathological conditions, in particular as a modulator of immune response and inflammation. Several properties exerted by Tα1 may be attributable to a direct action on lymphoid cells. Tα1 has been shown to exert an immune modulatory activity on both T cell and natural killer cell maturation and to have an effect on functions of mature lymphocytes, including stimulating cytokine production and cytotoxic T lymphocyte-mediated cytotoxic responses. In previous studies we have shown that Tα1 increases the expression of major histocompatibility complex class I surface molecules in murine and human tumor cell lines and in primary cultures of human macrophages. In the present paper, we describe preliminary data indicating that Tα1 is also capable of increasing the expression of tumor antigens in both experimental and human tumor cell lines. This effect, which is exerted at the level of the target tumor cells, represents an additional factor increasing the antitumor activity of Tα1.
KW - Cancer
KW - Immune effector cells
KW - Thymosin α1
KW - Tumor antigens
UR - http://www.scopus.com/inward/record.url?scp=84867384357&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867384357&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2012.06697.x
DO - 10.1111/j.1749-6632.2012.06697.x
M3 - Article
C2 - 23045967
AN - SCOPUS:84867384357
VL - 1269
SP - 26
EP - 33
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
IS - 1
ER -