Thymosin α1: The regulator of regulators?

Bonifazi Pierluigi, Carmen D'Angelo, Francesca Fallarino, Silvia Moretti, Teresa Zelante, Silvia Bozza, Antonella De Luca, Francesco Bistoni, Enrico Garaci, Luigina Romani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The peripheral immune system can promote either immunity or tolerance when presented with new antigens. Current knowledge withholds that populations of suppressor or regulatory T cells (Treg cells) constitute a pivotal mechanism of immunological tolerance. The potential role of malfunctioning Treg cells in chronic inflammatory immune and auto-immune diseases is well-documented. Learning how to successfully manipulate Treg responses could result in more effective vaccines and immunomodulators. We have already shown that Thymosin α1 (Tα1), a naturally occurring thymic peptide first described and characterized by Allan Goldstein in 1972, by modulating signals delivered through innate immune receptors on dendritic cells, affects adaptive immune responses via modulation of Th cell effector and regulatory functions. We will discuss recent molecular mechanisms underlying the ability of Tα1 to activate or inhibit immune responses.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages1-5
Number of pages5
Volume1194
DOIs
Publication statusPublished - Apr 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1194
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Dendritic cells
  • IDO
  • Infections
  • Regulatory T cells
  • Thymosin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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